Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood

EL Sullivan, MS Smith, KL Grove - Neuroendocrinology, 2011 - karger.com
… , Grove KL: Prenatal development of hypothalamic neuropeptide systems in the nonhuman
primate. Neuroscience 2006; 143: 975–986. 63 Grayson BE, Kievit P, Smith MS, Grove KL: …

Ontogeny of the hypothalamic neuropeptide Y system

KL Grove, MS Smith - Physiology & behavior, 2003 - Elsevier
Early onset obesity and type II diabetes is rapidly becoming an epidemic, especially within
the United States. This dramatic increase is likely due to many factors including both prenatal …

Development of metabolic systems

KL Grove, BE Grayson, MM Glavas, XQ Xiao… - Physiology & …, 2005 - Elsevier
In the normal adult rodent and primate, arcuate nucleus (ARH) neurons function as conduits
for transmitting metabolic hormonal signals into the hypothalamic circuitry that modulates …

[PDF][PDF] The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis

…, RG Smith, S Diano, M Tschöp, N Pronchuk, KL Grove… - Neuron, 2003 - cell.com
The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via
hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized …

[HTML][HTML] The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

…, LS Dalbøge, G Hansen, KL Grove… - The Journal of …, 2014 - Am Soc Clin Investig
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2
diabetes. Besides lowering blood glucose, liraglutide also reduces body weight. It is not fully …

[HTML][HTML] Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

…, MS Smith, JE Friedman, KL Grove - The Journal of …, 2009 - Am Soc Clin Investig
… This work was funded by NIH grants DK-60685 (to KL Grove), DK-79194 (to KL Grove),
RR00163 (to KL Grove and ONPRC), DKF32-075252 (to CE McCurdy), and DK-062155 (to JE …

[PDF][PDF] Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons

…, BE Grayson, M Perello, EA Nillni, KL Grove… - Cell metabolism, 2007 - cell.com
Despite high leptin levels, most obese humans and rodents lack responsiveness to its
appetite-suppressing effects. We demonstrate that leptin modulates NPY/AgRP and α-MSH …

[HTML][HTML] High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model

…, P Blundell, R Alan Harris, AE Frias, KL Grove… - Nature …, 2014 - nature.com
The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism
and obesity in mammals. However, studies investigating the impact of the diet on the …

Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition

…, J Rasanen, KY Oh, KL Thornburg, KL Grove - …, 2011 - academic.oup.com
Prepregnancy maternal obesity confers an increased risk of stillbirth, but the mechanisms are
unknown. Maternal obesity is associated with placental inflammation. We considered that …

Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate …

…, MS Smith, K Coleman, KL Grove - Journal of …, 2010 - Soc Neuroscience
Childhood obesity is associated with increased risk of behavioral/psychological disorders
including depression, anxiety, poor learning, and attention deficient disorder. As the majority of …