Voltage-dependent L-type Ca 2+ channels are multisubunit transmembrane proteins, which
allow the influx of Ca 2+ (I Ca ) essential for normal excitability and excitation-contraction …

Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant
protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases, …

The establishment of neural circuitry requires vast numbers of synapses to be generated
during a specific window of brain development, but it is not known why the developing …

… JW Hell and RE Westenbroek contributed equally to this work. Address all correspondence
to WA Catterall, Department of Pharmacology, SJ-30, University of Washington, Seattle, WA …

Calcium- and calmodulin-dependent protein kinase II (CaMKII) and glutamate receptors are
integrally involved in forms of synaptic plasticity that may underlie learning and memory. In …

A site-directed anti-peptide antibody (anti-CNA1) directed against the alpha 1 subunit of
class A calcium channels (alpha 1A) recognized a protein of approximately 190-200 kDa in …

A site-directed anti-peptide antibody, CNB-1, that recognizes the α1 subunit of rat brain class
B calcium channels (rbB) immunoprecipitated 43% of the N-type calcium channels labeled …

The membrane-associated guanylate kinases [Chapsyn-110/postsynaptic density-93 (PSD-93),
synapse-associated protein-90 (SAP-90)/PSD-95, and SAP-102] are believed to cluster …

The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide
binding proteins (G proteins) raises the question of how a particular receptor selectively …