User profiles for J. N. Stankowski
Jeannette StankowskiInstructor in Neuroscience Verified email at mayo.edu Cited by 2839 |
C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
…, PO Bauer, EC Whitelaw, L Rousseau, JN Stankowski… - Science, 2015 - science.org
The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…
[HTML][HTML] Aggregation-prone c9FTD/ALS poly (GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation
of expanded repeats that results in the synthesis of homopolymeric expansion proteins, …
of expanded repeats that results in the synthesis of homopolymeric expansion proteins, …
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
…, M Shinohara, WL Lin, A Garrett, JN Stankowski… - Nature …, 2016 - nature.com
Neuronal inclusions of poly(GA), a protein unconventionally translated from G 4 C 2 repeat
expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and …
expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and …
Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis
There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor
neuron disease. However, discovery of a G 4 C 2 repeat expansion in the C9ORF72 gene as …
neuron disease. However, discovery of a G 4 C 2 repeat expansion in the C9ORF72 gene as …
(Patho‐) physiological relevance of PINK 1‐dependent ubiquitin phosphorylation
…, EL Moussaud‐Lamodière, JN Stankowski… - EMBO …, 2015 - embopress.org
Mutations in PINK 1 and PARKIN cause recessive, early‐onset Parkinson's disease ( PD ).
Together, these two proteins orchestrate a protective mitophagic response that ensures the …
Together, these two proteins orchestrate a protective mitophagic response that ensures the …
[HTML][HTML] Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
…, M Castanedes-Casey, A Kurti, JN Stankowski… - Molecular …, 2019 - Springer
Background AG 4 C 2 hexanucleotide repeat expansion in the noncoding region of C9orf72
is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (…
is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (…
[HTML][HTML] Acetylation: a new key to unlock tau's role in neurodegeneration
C Cook, JN Stankowski, Y Carlomagno… - Alzheimer's research & …, 2014 - Springer
The identification of tau protein as a major constituent of neurofibrillary tangles spurred
considerable effort devoted to identifying and validating pathways through which therapeutics …
considerable effort devoted to identifying and validating pathways through which therapeutics …
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
…, DJ Anderson, JN Stankowski… - Journal of …, 2009 - Wiley Online Library
Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins
and lipids. Excessive environmental exposure to manganese can produce extrapyramidal …
and lipids. Excessive environmental exposure to manganese can produce extrapyramidal …
[HTML][HTML] The lysosomal protein cathepsin L is a progranulin protease
CW Lee, JN Stankowski, J Chew, CN Cook… - Molecular …, 2017 - Springer
Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal
lobar degeneration (FTLD), the second most common cause of early-onset dementia. …
lobar degeneration (FTLD), the second most common cause of early-onset dementia. …
Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation?
JN Stankowski, R Gupta - Antioxidants & redox signaling, 2011 - liebertpub.com
The development of a suitable neuroprotective agent to treat ischemic stroke has failed when
transitioned to the clinical setting. An understanding of the molecular mechanisms involved …
transitioned to the clinical setting. An understanding of the molecular mechanisms involved …