The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G
4 C 2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with “…

The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation
of expanded repeats that results in the synthesis of homopolymeric expansion proteins, …

Neuronal inclusions of poly(GA), a protein unconventionally translated from G 4 C 2 repeat
expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and …

There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor
neuron disease. However, discovery of a G 4 C 2 repeat expansion in the C9ORF72 gene as …

Mutations in PINK 1 and PARKIN cause recessive, early‐onset Parkinson's disease ( PD ).
Together, these two proteins orchestrate a protective mitophagic response that ensures the …

Background AG 4 C 2 hexanucleotide repeat expansion in the noncoding region of C9orf72
is the major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (…

The identification of tau protein as a major constituent of neurofibrillary tangles spurred
considerable effort devoted to identifying and validating pathways through which therapeutics …

Manganese is an essential nutrient, integral to proper metabolism of amino acids, proteins
and lipids. Excessive environmental exposure to manganese can produce extrapyramidal …

Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal
lobar degeneration (FTLD), the second most common cause of early-onset dementia. …

The development of a suitable neuroprotective agent to treat ischemic stroke has failed when
transitioned to the clinical setting. An understanding of the molecular mechanisms involved …