User profiles for J. M. Nerbonne
Jeanne M. NerbonneWashington University Medical School Verified email at wustl.edu Cited by 62160 |
Molecular physiology of cardiac repolarization
JM Nerbonne, RS Kass - Physiological reviews, 2005 - journals.physiology.org
The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …
potential generation and propagation, followed by relaxation and a period of refractoriness …
Molecular basis of functional voltage‐gated K+ channel diversity in the mammalian myocardium
JM Nerbonne - The Journal of physiology, 2000 - Wiley Online Library
… Li & JM Nerbonne, unpublished observations). In spite of the terminology, I K,slow ,
which is rapidly activating and slowly inactivating and is blocked selectively by micromolar …
which is rapidly activating and slowly inactivating and is blocked selectively by micromolar …
Genetic Manipulation of Cardiac K+ Channel Function in Mice: What Have We Learned, and Where Do We Go From Here?
JM Nerbonne, CG Nichols, TL Schwarz… - Circulation …, 2001 - Am Heart Assoc
In the mammalian myocardium, potassium (K + ) channels control resting potentials, action
potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple …
potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple …
[HTML][HTML] Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
…, C Keller-Peck, QT Nguyen, M Wallace, JM Nerbonne… - Neuron, 2000 - cell.com
We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins (together
termed XFPs) were selectively expressed in neurons. All four XFPs labeled neurons in …
termed XFPs) were selectively expressed in neurons. All four XFPs labeled neurons in …
Atrial L-Type Ca2+ Currents and Human Atrial Fibrillation
…, SS Rossie, PM McCarthy, JM Nerbonne - Circulation …, 1999 - Am Heart Assoc
Chronic atrial fibrillation (AF) is characterized by decreased atrial contractility, shortened
action potential duration, and decreased accommodation of action potential duration to …
action potential duration, and decreased accommodation of action potential duration to …
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
…, R Kwong, DA Lathrop, AM Mascette, JM Nerbonne… - Circulation, 2010 - Am Heart Assoc
Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 US …
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 US …
Outward K+ Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation
…, PM McCarthy, JS Trimmer, JM Nerbonne - Circulation …, 1997 - Am Heart Assoc
Chronic atrial fibrillation is associated with a shortening of the atrial action potential duration
and atrial refractory period. To test the hypothesis that these changes are mediated by …
and atrial refractory period. To test the hypothesis that these changes are mediated by …
A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content
…, M Courtois, F Aimond, JM Nerbonne… - Proceedings of the …, 2003 - National Acad Sciences
To explore the role of peroxisome proliferator-activated receptor α (PPARα)-mediated
derangements in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, …
derangements in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, …
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
…, KA Yamada, S Brunet, H Xu, JM Nerbonne… - Circulation …, 2005 - Am Heart Assoc
Evidence is emerging that systemic metabolic disturbances contribute to cardiac myocyte
dysfunction and clinically apparent heart failure, independent of associated coronary artery …
dysfunction and clinically apparent heart failure, independent of associated coronary artery …
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts
…, G Condorelli, A Diwan, JM Nerbonne… - Circulation …, 2010 - Am Heart Assoc
Rationale: MicroRNA (miR)-133a regulates cardiac and skeletal muscle differentiation and
plays an important role in cardiac development. Because miR-133a levels decrease during …
plays an important role in cardiac development. Because miR-133a levels decrease during …