Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk
haematological malignant disorders and other life-threatening haematological and genetic …

… & Dick, JE Human acute myeloid leukemia is organized as a hierarchy that originates from a
… We dedicate this work to the late Stanley J. Korsmeyer, whose scientific vision inspired the …

Acute graft-versus-host disease (GVHD) remains a leading cause of morbidity and nonrelapse
mortality after allogeneic hematopoietic cell transplantation. The clinical staging of GVHD …

Next-generation sequencing of the hypervariable V3 region of the 16s rRNA gene isolated
from serial stool specimens collected from 31 patients receiving allogeneic stem cell …

Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning
pain by selectively activating sensory neurons that convey information about noxious stimuli …

We identified genetic mutations in CD19 and loss of heterozygosity at the time of CD19 –
relapse to chimeric antigen receptor (CAR) therapy. The mutations are present in the vast …

No validated biomarkers exist for acute graft-versus-host disease (GVHD). We screened
plasma with antibody microarrays for 120 proteins in a discovery set of 42 patients who …

Background No plasma biomarkers are associated with the response of acute graft-versus-host
disease (GVHD) to therapy after allogeneic hematopoietic stem-cell transplantation. …

Rho GTPases control a variety of cellular processes, including actin polymerization, integrin
complex formation, cell adhesion, gene transcription, cell cycle progression, and cell …

Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells,
often within the same patient. Intratumor phenotypic and functional heterogeneity have been …