User profiles for E. Ling-lin Pai
Emily Ling-Lin PaiUniversity of California, San Francisco; Johns Hopkins University Verified email at ucsf.edu Cited by 643 |
[PDF][PDF] Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors
…, C Chen, E Dumontier, S Falkner, E Furlanis… - Neuron, 2020 - cell.com
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin,
and reporter expression in the mouse nervous system. However, we report varying …
and reporter expression in the mouse nervous system. However, we report varying …
[PDF][PDF] Neonatal Tbr1 dosage controls cortical layer 6 connectivity
…, SER Schwartz, Q Qi, R Catta-Preta, ELL Pai… - Neuron, 2018 - cell.com
An understanding of how heterozygous loss-of-function mutations in autism spectrum disorder
(ASD) risk genes, such as TBR1, contribute to ASD remains elusive. Conditional Tbr1 …
(ASD) risk genes, such as TBR1, contribute to ASD remains elusive. Conditional Tbr1 …
[PDF][PDF] Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes
Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo
Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum …
Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum …
[PDF][PDF] Enhancing WNT signaling restores cortical neuronal spine maturation and synaptogenesis in Tbr1 mutants
Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription
factor with distinct pre- and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) …
factor with distinct pre- and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) …
[HTML][HTML] Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
… e Voltage clamp recordings were obtained from pyramidal neurons while activating ChR2-expressing
SST+ CINs. f Example optogenetically-activated IPSCs (oIPSCs) recorded in WTs (…
SST+ CINs. f Example optogenetically-activated IPSCs (oIPSCs) recorded in WTs (…
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation
… – G’’’) Higher magnification fluorescent images of multiplex RNA in situ hybridization for
Mef2c (E–E’’’), Sp9 (F–F’’’) and Igfbp4 (G–G’’’). White arrows point to INs that are marker (Mef2c, …
Mef2c (E–E’’’), Sp9 (F–F’’’) and Igfbp4 (G–G’’’). White arrows point to INs that are marker (Mef2c, …
[PDF][PDF] Mafb and c-Maf have prenatal compensatory and postnatal antagonistic roles in cortical interneuron fate and function
Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence
(MGE) lineages, beginning in late-secondary progenitors and continuing into mature …
(MGE) lineages, beginning in late-secondary progenitors and continuing into mature …
Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons
K Angara, ELL Pai, SM Bilinovich… - Proceedings of the …, 2020 - National Acad Sciences
… In situ hybridization to detect Nf1 RNA in P30 neocortices in the same genotypes at P30 (E–G).
(H) Quantification of Nf1 + cells in the neocortex at P30. Data are … Emily Ling-Lin Pai …
(H) Quantification of Nf1 + cells in the neocortex at P30. Data are … Emily Ling-Lin Pai …
The AAA+ ATPase Thorase is neuroprotective against ischemic injury
Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to
new protein expression that mediates a profound neuroprotection against glutamate …
new protein expression that mediates a profound neuroprotection against glutamate …
High-content genome-wide RNAi screen reveals CCR3 as a key mediator of neuronal cell death
Neuronal loss caused by ischemic injury, trauma, or disease can lead to devastating
consequences for the individual. With the goal of limiting neuronal loss, a number of cell death …
consequences for the individual. With the goal of limiting neuronal loss, a number of cell death …