User profiles for E. Ling-lin Pai

Emily Ling-Lin Pai

University of California, San Francisco; Johns Hopkins University
Verified email at ucsf.edu
Cited by 643

[PDF][PDF] Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors

…, C Chen, E Dumontier, S Falkner, E Furlanis… - Neuron, 2020 - cell.com
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin,
and reporter expression in the mouse nervous system. However, we report varying …

[PDF][PDF] Neonatal Tbr1 dosage controls cortical layer 6 connectivity

…, SER Schwartz, Q Qi, R Catta-Preta, ELL Pai… - Neuron, 2018 - cell.com
An understanding of how heterozygous loss-of-function mutations in autism spectrum disorder
(ASD) risk genes, such as TBR1, contribute to ASD remains elusive. Conditional Tbr1 …

[PDF][PDF] Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

…, J Price, K Lim, AR Ypsilanti, R Catta-Preta, ELL Pai… - Cell reports, 2021 - cell.com
Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo
Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum …

[PDF][PDF] Enhancing WNT signaling restores cortical neuronal spine maturation and synaptogenesis in Tbr1 mutants

SF Darbandi, SER Schwartz, ELL Pai, A Everitt… - Cell reports, 2020 - cell.com
Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription
factor with distinct pre- and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) …

[HTML][HTML] Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons

R Malik, ELL Pai, AN Rubin, AM Stafford… - Nature …, 2019 - nature.com
e Voltage clamp recordings were obtained from pyramidal neurons while activating ChR2-expressing
SST+ CINs. f Example optogenetically-activated IPSCs (oIPSCs) recorded in WTs (…

Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation

ELL Pai, J Chen, S Fazel Darbandi, FS Cho, J Chen… - Elife, 2020 - elifesciences.org
… – G’’’) Higher magnification fluorescent images of multiplex RNA in situ hybridization for
Mef2c (EE’’’), Sp9 (F–F’’’) and Igfbp4 (G–G’’’). White arrows point to INs that are marker (Mef2c, …

[PDF][PDF] Mafb and c-Maf have prenatal compensatory and postnatal antagonistic roles in cortical interneuron fate and function

ELL Pai, D Vogt, A Clemente-Perez, GL McKinsey… - Cell reports, 2019 - cell.com
Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence
(MGE) lineages, beginning in late-secondary progenitors and continuing into mature …

Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons

K Angara, ELL Pai, SM Bilinovich… - Proceedings of the …, 2020 - National Acad Sciences
… In situ hybridization to detect Nf1 RNA in P30 neocortices in the same genotypes at P30 (E–G).
(H) Quantification of Nf1 + cells in the neocortex at P30. Data are … Emily Ling-Lin Pai

The AAA+ ATPase Thorase is neuroprotective against ischemic injury

…, MJ Keuss, GKE Umanah, ELL Pai… - Journal of Cerebral …, 2019 - journals.sagepub.com
Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to
new protein expression that mediates a profound neuroprotection against glutamate …

High-content genome-wide RNAi screen reveals CCR3 as a key mediator of neuronal cell death

J Zhang, H Wang, O Sherbini, EL Pai, SU Kang… - Eneuro, 2016 - eneuro.org
Neuronal loss caused by ischemic injury, trauma, or disease can lead to devastating
consequences for the individual. With the goal of limiting neuronal loss, a number of cell death …