User profiles for D. Sinclair

David A. Sinclair

- Verified email at hms.harvard.edu - Cited by 91795

Derek C Sinclair

- Verified email at sheffield.ac.uk - Cited by 23784

David Sinclair

- Verified email at cunet.carleton.ca - Cited by 21773

Therapeutic potential of resveratrol: the in vivo evidence

JA Baur, DA Sinclair - Nature reviews Drug discovery, 2006 - nature.com
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its identification …

Electroceramics: characterization by impedance spectroscopy

JTS Irvine, DC Sinclair, AR West - Advanced materials, 1990 - Wiley Online Library
D. topic was on photoelectrochemistry and his research interests have expanded to
include high- ceramic superconductors, solid electrolytes and solid state electrochemistry. …

Mammalian sirtuins: biological insights and disease relevance

MC Haigis, DA Sinclair - Annual Review of Pathology …, 2010 - annualreviews.org
Aging is accompanied by a decline in the healthy function of multiple organ systems,
leading to increased incidence and mortality from diseases such as type II diabetes mellitus, …

Resveratrol improves health and survival of mice on a high-calorie diet

…, P Puigserver, DK Ingram, R De Cabo, DA Sinclair - Nature, 2006 - nature.com
Resveratrol (3,5,4′-trihydroxystilbene) extends the lifespan of diverse species including
Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these …

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

…, A Kisielewski, LL Zhang, B Scherer, DA Sinclair - Nature, 2003 - nature.com
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum
lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan …

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

…, KT Howitz, M Gorospe, R De Cabo, DA Sinclair - science, 2004 - science.org
A major cause of aging is thought to result from the cumulative effects of cell loss over time.
In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we …

Direct evidence for neutrino flavor transformation from neutral-current interactions in the Sudbury Neutrino Observatory

…, H Seifert, M Shatkay, JJ Simpson, CJ Sims, D Sinclair… - Physical review …, 2002 - APS
Observations of neutral-current ν interactions on deuterium in the Sudbury Neutrino
Observatory are reported. Using the neutral current (NC), elastic scattering, and charged current …

Observation of a neutrino burst in coincidence with supernova 1987A in the Large Magellanic Cloud

…, F Reines, J Schultz, S Seidel, E Shumard, D Sinclair… - Physical Review Letters, 1987 - APS
A burst of eight neutrino events preceding the optical detection of the supernova in the Large
Magellanic cloud has been observed in a large underground water Cherenkov detector. The …

[HTML][HTML] Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

…, A Rosenzweig, R de Cabo, AA Sauve, DA Sinclair - Cell, 2007 - cell.com
A major cause of cell death caused by genotoxic stress is thought to be due to the depletion
of NAD + from the nucleus and the cytoplasm. Here we show that NAD + levels in …

Measurement of day and night neutrino energy spectra at SNO and constraints on neutrino mixing parameters

…, M Shatkay, JJ Simpson, CJ Sims, D Sinclair… - Physical Review Letters, 2002 - APS
The Sudbury Neutrino Observatory (SNO) has measured day and night solar neutrino energy
spectra and rates. For charged current events, assuming an undistorted 8 B spectrum, the …