Objectives To examine the effects of aerobic exercise on cognition and other biomarkers
associated with Alzheimer disease pathology for older adults with mild cognitive impairment, …

Background: Reduced brain insulin signaling and low CSF-to-plasma insulin ratios have been
observed in patients with Alzheimer disease (AD). Furthermore, intracerebroventricular or …

BACKGROUND: Preclinical research findings suggest that exposure to stress and concomitant
hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have …

Pineal melatonin secretion declines with aging, whereas visceral fat, plasma insulin, and
plasma leptin tend to increase. We have previously demonstrated that daily melatonin …

Research suggests that disruptions in early caretaking can have long-term effects on the
hypothalamic–pituitary–adrenal (HPA) axis, which mediates the stress response. Children of …

In the present article, we report on two studies performed in young human populations which
tested the cognitive impact of glucocorticoids (GC) in situations of decreased or increased …

Anthropogenic climate change and increasing antimicrobial resistance (AMR) together
threaten the last 50 years of public health gains. Honey bees are a model One Health organism …

Background Increasing plasma glucose levels improves memory in patients with Alzheimer
disease (AD). Increasing plasma glucose levels also increases endogenous insulin levels, …

… Charles Wilkinson's laboratory using a 125–I cortisol kit from Pantex (Santa Monica, CA),
modified for use with saliva samples. Salivettes were centrifuged at 4C at approximately 1800 g …

Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM)
pathology and has been linked to increased risk of cognitive impairment and dementia. …