Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications

B Fritzsch, U Pirvola, J Ylikoski - Cell and tissue research, 1999 - Springer
Analyses of single and double mutants of members of the neurotrophin family and their
receptors are reviewed. These data demonstrate that the two neurotrophins, brain-derived …

The K+/Cl co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

…, E Ruusuvuori, H Lahtinen, K Lamsa, U Pirvola… - Nature, 1999 - nature.com
… 20 U RNAse inhibitor, 0.1 µg yeast tRNA, and 1 U RNAse-free DNAase I (Boehringer) in (in
mM): 120 KCl, 5 MgCl 2 , 10 HEPES (pH 7.4). The cell-containing solution was collected in a …

Histamine-immunoreactive nerve fibers in the rat brain

P Panula, U Pirvola, S Auvinen, MS Airaksinen - Neuroscience, 1989 - Elsevier
A new immunohistochemical method that utilizes carbodiimide as a tissue fixative was applied
to study the distribution of histamine-immunoreactive neuronal fibers and terminals in the …

Rescue and regrowth of sensory nerves following deafferentation by neurotrophic factors

…, Y Cho, J Ylikoski, U Pirvola… - Annals of the New …, 1999 - Wiley Online Library
Trauma and loss of cochlear inner hair cells causes a series of events that result first in the
retraction of the peripheral processes of the auditory nerve, scar formation in the organ of Corti…

Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear

J Ylikoski, U Pirvola, M Moshnyakov, J Palgi, U Arumäe… - Hearing research, 1993 - Elsevier
… ce,fI Strong expression of BDNF mRNA is seen in the sensory emthe :lia of the utricular
macula (U) and ampullary crista (A). (g,h) NGF mRNA is not seen in the sensory epithelia of …

Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

U Pirvola, L Xing-Qun, J Virkkala… - Journal of …, 2000 - Soc Neuroscience
… The JNK pathway is activated in cisplatin-treated hair cells in vitro (U. Pirvola and L. Xing-Qun,
unpublished observations). These data suggest that, in addition to aminoglycoside-…

Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.

U Pirvola, J Ylikoski, J Palgi… - Proceedings of the …, 1992 - National Acad Sciences
In situ hybridization was used to study the site and timing of the expression of nerve growth
factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and …

[HTML][HTML] FGFR1 is required for the development of the auditory sensory epithelium

U Pirvola, J Ylikoski, R Trokovic, JM Hébert… - Neuron, 2002 - cell.com
The mammalian auditory sensory epithelium, the organ of Corti, comprises the hair cells and
supporting cells that are pivotal for hearing function. The origin and development of their …

A histamine-containing neuronal system in human brain

P Panula, MS Airaksinen, U Pirvola, E Kotilainen - Neuroscience, 1990 - Elsevier
A well-organized network of varicose fibers was revealed throughout the frontal and temporal
cortex of adult humans with specific antisera against histamine. The densest network of …

[PDF][PDF] Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3

…, S Tegelberg, P Gasparini, L Zelante, U Pirvola… - The American Journal of …, 2001 - cell.com
Usher syndrome type 3 (USH3) is an autosomal recessive disorder characterized by progressive
hearing loss, severe retinal degeneration, and variably present vestibular dysfunction, …