… In keeping with this hypothesis, we have recently observed that antidepressants indeed
increase the phosphorylation of TrkB in mice with reduced BDNF expression (Rantamäki and …

… the extracellular signal-regulated kinase pathway, but does activate phospholipase-Cγ
signaling and lead to the phosphorylation of cAMP-related element binding protein (Rantamäki …

Brain-derived neurotrophic factor (BDNF) is a critical mediator of activity-dependent neuronal
plasticity in the cerebral cortex. Deficits in neurotrophic factors have been proposed to …

Previous studies suggest that brain-derived neurotrophic factor and its receptor TrkB are
critically involved in the therapeutic actions of antidepressant drugs. We have previously shown …

Batten disease (juvenile-onset neuronal ceroid lipofuscinosis, JNCL), the most common
neurodegenerative disorder of childhood, is caused by mutations in a recently identified gene (…

Background Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived
neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this …

1. Neurotrophins and serotonin have both been implicated in the pathophysiology of
depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic …

… Relative expression levels of the targets were calculated with the comparative cycle threshold
(C T ) method according to the following formula: sample ΔC T = (gene C T − actbC T ). To …

… For comparison between two groups, a two tailed Student’s t-… when compared to control
group (Student’s unpaired t-test). … when compared to control group (Student’s unpaired t-test). …

… in TBS-T (10 minutes) and incubated (1 hour, room temperature) with the secondary antibodies
diluted (see supplementary Table 1) in 5% low fat dry milk TBS-T. After 3 washes in TBS-…