Many important physiological processes operate at time and space scales far beyond those
accessible to atom-realistic simulations, and yet discrete stochastic rather than continuum …

Microphysiological Models............................................................................ 89 4.2. 1 Model
Design..................................................................................... 89 4.2. 2 Simulations Based on …

10.7554/eLife.10778.001 Information in a computer is quantified by the number of bits that
can be stored and recovered. An important question about the brain is how much information …

We recorded miniature endplate currents (mEPCs) using simultaneous voltage clamp and
extracellular methods, allowing correction for time course measurement errors. We obtained a …

We have developed a biophysically realistic model of receptor activation at an idealized
central glutamatergic synapse that uses Monte Carlo techniques to simulate the stochastic …

A Monte Carlo method for modeling the neuromuscular junction is described in which the
three-dimensional structure of the synapse can be specified. Complexities can be introduced …

Neurotransmitter release is well known to occur at specialized synaptic regions that include
presynaptic active zones and postsynaptic densities. At cholinergic synapses in the chick …

The nanoscale organization of neurotransmitter receptors regarding pre-synaptic release
sites is a fundamental determinant of the synaptic transmission amplitude and reliability. How …

Although the extracellular space in the neuropil of the brain is an important channel for volume
communication between cells and has other important functions, its morphology on the …

The crowded intracellular environment poses a formidable challenge to experimental and
theoretical analyses of intracellular transport mechanisms. Our measurements of single-…