[PDF][PDF] Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons

S Threlfell, T Lalic, NJ Platt, KA Jennings, K Deisseroth… - Neuron, 2012 - cell.com
… Hypo- or hypercholinergic states implicated in basal ganglia disorders including PD,
Huntington’s, Tourette’s, and dystonia and in the … This work was supported by a Parkinson’s UK …

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

S Janezic, S Threlfell, PD Dodson… - Proceedings of the …, 2013 - National Acad Sciences
… No “amyloid” pathology was detected with thioflavine S in either 18-mo-old SNCA-OVX or
Snca −/− , whereas several Lewy bodies and dystrophic neurites were detected in the positive …

Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family

…, N Doig, N Connor-Robson, S Threlfell… - Journal of …, 2011 - Soc Neuroscience
The synucleins (α, β, and γ) are highly homologous proteins thought to play a role in
regulating neurotransmission and are found abundantly in presynaptic terminals. To overcome …

Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal …

S Threlfell, MA Clements, T Khodai… - Journal of …, 2010 - Soc Neuroscience
Striatal dopamine (DA) and acetylcholine (ACh) regulate motivated behaviors and striatal
plasticity. Interactions between these neurotransmitters may be important, through …

[HTML][HTML] Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons

S Threlfell, SJ Cragg - Frontiers in systems neuroscience, 2011 - frontiersin.org
… M 1 -like receptors are coupled to the G s class of G α proteins, whereas M 2 -like receptors
are coupled to G i proteins, thereby modulating different intracellular signaling pathways. The …

Modulation of striatal neuron activity by cyclic nucleotide signalling and phosphodiesterase inhibition

S Threlfell, AR West - Basal ganglia, 2013 - Elsevier
… In most cases neurotransmitter receptors are functionally coupled to AC via either a
stimulatory (G olf , G s ) or inhibitory G-protein (G i ) (see [1] for review). Additionally, the resulting …

Cortical control of striatal dopamine transmission via striatal cholinergic interneurons

P Kosillo, YF Zhang, S Threlfell, SJ Cragg - Cerebral cortex, 2016 - academic.oup.com
… A triangular waveform was applied to carbon fiber scanning from −0.7 V to +1.3 V and
back, against Ag/AgCl reference electrode at a rate of 800 V/s. Evoked DA transients were …

Distinct contributions of nicotinic acetylcholine receptor subunit α4 and subunit α6 to the reinforcing effects of nicotine

…, A Evrard, S Pons, F Marti, S Threlfell… - Proceedings of the …, 2011 - National Acad Sciences
… In α4 −/− mice, nicotine-elicited increases in firing rate were delayed (∼100 s) and markedly
attenuated compared with those in WT mice (Wilcoxon rank sum test; W = 147, P = 0.04163; …

Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata

S Threlfell, SJ Cragg, I Kalló, GF Turi… - Journal of …, 2004 - Soc Neuroscience
… B, Evoked [5-HT] o was not significantly modified by inclusion of glutamate receptor
antagonists [(S)-MCPG, 200 μm; d-AP-5, 50 μm; GYKI52466, 10 μm; n = 12]. In the presence of …

Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation

S Threlfell, S Sammut, FS Menniti, CJ Schmidt… - … of Pharmacology and …, 2009 - ASPET
The cyclic nucleotide phosphodiesterase 10A (PDE10A) is highly expressed in striatal
medium-sized spiny projection neurons (MSNs), apparently playing a critical role in the regulation …