Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled
receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of …

INTRODUCTION Poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is a nuclear enzyme
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …

Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded
to include their roles in neurodegeneration. Investigations have begun to reveal the …

Stroke is a major cause of mortality and morbidity worldwide. Extracellular glutamate
accumulation leading to overstimulation of the ionotropic glutamate receptors mediates neuronal …

The male sex steroid, testosterone (T), is synthesized from cholesterol in the testicular Leydig
cell under control of the pituitary gonadotropin LH. Unlike most cells that use cholesterol …

Translation initiation generally occurs at AUG codons in eukaryotes, although it has been
shown that non-AUG or noncanonical translation initiation can also occur. However, the …

Translating neuroprotective treatments from discovery in cell and animal models to the clinic
has proven challenging. To reduce the gap between basic studies of neurotoxicity and …

Sertoli cell tight junctions (SCTJs) of the seminiferous epithelium create a specialized
microenvironment in the testis to aid differentiation of spermatocytes and spermatids from …

Neuronal activity regulates a broad range of processes in the hippocampus, including the
precise regulation of translation. Disruptions in proper translational control in the nervous …

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial
Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via …