Perturbations of the endolysosomal pathway have been suggested to play an important role
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (…

The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.)
nuclear content. Polyploid hepatocytes are commonly found in adult mammals, …

Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to development of late-onset
familial Parkinson's disease (PD), with clinical features of motor and cognitive dysfunction …

A defining feature of the mammalian liver is polyploidy, a numerical change in the entire
complement of chromosomes. The first step of polyploidization involves cell division with failed …

Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a
cytoprotective protein that is dysregulated in inflammatory lung injury and neurodegenerative …

The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid, etc.), with polyploids
comprising ≥90% of the hepatocyte population in adult mice. Polyploid hepatocytes form …

The transplantation of rodent Schwann cells (SCs) provides anatomical and functional
restitution in a variety of spinal cord injury (SCI) models, supporting the recent translation of SCs …

There are currently no treatments that hinder or halt the inexorable progression of Parkinson’s
disease (PD). While the etiology of PD remains elusive, evidence suggests that early …

This study aims at assessing the effects of social relationships on the survival, functional
ability and mental health of the elderly, through a review of the published evidence in …

While PTEN-induced kinase 1 (PINK1) is well characterized for its role in mitochondrial
homeostasis, much less is known concerning its ability to prevent synaptodendritic degeneration. …