Central amygdala neurons expressing protein kinase C-delta (CeA-PKCδ) are sensitized
following nerve injury and promote pain-related responses in mice. The neural circuits …

Studies suggest that plasticity in the infralimbic prefrontal cortex (IL) in rodents and its homolog
in humans is necessary for inhibition of fear during the recall of fear extinction. The recall …

Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging
in brain tissue remains challenging. Here, we describe a conditional mouse genetic strategy …

The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive
information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission in …

The factors influencing resiliency to the development of post-traumatic stress disorder (PTSD)
remain to be elucidated. Clinical studies associate PTSD with polymorphisms of the FK506 …

Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development
for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a …

Patients with posttraumatic stress disorder (PTSD) show hypo-active ventromedial prefrontal
cortices (vmPFC) that correlate with their impaired ability to discriminate between safe and …

G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid
receptor. However, little is known about its functional role in cannabinoid action and substance …

Preclinical research has demonstrated the efficacy of CB1 receptor (CB1R) antagonists in
reducing drug-taking behavior. However, clinical trials with rimonabant, a CB1R antagonist …

The medial prefrontal cortex (mPFC) processes contextual information from the hippocampus
to generate appropriate fear responses. In rodents, one path for sending contextual …