In mammals, dosage compensation is achieved by X inactivation 1 and is regulated in cis
by the X-inactivation centre 2 (Xic) and Xist (refs 3, 4, 5). The Xic controls X-chromosome …

The genes for two new P-type ATPases, PMRl and PMRP, have been identified in yeast. A
comparison of the deduced sequences of the PMR proteins with other known ion pumps …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease,
characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here…

In mammals, X-inactivation silences one of two female X chromosomes. Silencing depends
on the noncoding gene, Xist(inactive X-specifictranscript), and is blocked by the antisense …

10.7554/eLife.02809.001 Dysfunction or death of pancreatic β cells underlies both types of
diabetes. This functional decline begins with β cell stress and de-differentiation. Current …

Human pluripotent stem cells (hPSCs) offer a renewable source of cells that can be expanded
indefinitely and differentiated into virtually any type of cell in the human body, including …

… Offprint requests to: LS Davidow … LS Davidow et al.: Integrative transformation of Y.
lipolytica … LS Davidow et al.: Integrative transformation of K lipolytica …

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to
increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting …

The motor neuron disease spinal muscular atrophy (SMA) results from mutations that lead
to low levels of the ubiquitously expressed protein survival of motor neuron (SMN). An ever-…

The mechanism underlying selective motor neuron (MN) death remains an essential question
in the MN disease field. The MN disease spinal muscular atrophy (SMA) is attributable to …