Induction of neuronal death by ER stress in Alzheimer's disease
T Katayama, K Imaizumi, T Manabe, J Hitomi… - Journal of chemical …, 2004 - Elsevier
Recent studies have suggested that neuronal death in Alzheimer’s disease (AD) or ischemia
could arise from dysfunction of the endoplasmic reticulum (ER). Inhibition of protein …
could arise from dysfunction of the endoplasmic reticulum (ER). Inhibition of protein …
The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology
…, S Kondo, A Saito, K Imaizumi - The journal of …, 2011 - academic.oup.com
Eukaryotic cells can adapt to endoplasmic reticulum (ER) dysfunction by producing diverse
signals from the ER to the cytosol or nucleus. These signalling pathways are collectively …
signals from the ER to the cytosol or nucleus. These signalling pathways are collectively …
[HTML][HTML] The unfolded protein response and Alzheimer's disease
K Imaizumi, K Miyoshi, T Katayama, T Yoneda… - … et Biophysica Acta (BBA …, 2001 - Elsevier
… Katayama and K. Imaizumi, unpublished observations), indicating that mutant PS1 perturbs
functions of each ER stress transducer and causes the resultant downregulation of its …
functions of each ER stress transducer and causes the resultant downregulation of its …
Autophagy is activated for cell survival after endoplasmic ReticulumStress
…, JA Hammarback, F Urano, K Imaizumi - … and cellular biology, 2006 - Taylor & Francis
Eukaryotic cells deal with accumulation of unfolded proteins in the endoplasmic reticulum (ER)
by the unfolded protein response, involving the induction of molecular chaperones, …
by the unfolded protein response, involving the induction of molecular chaperones, …
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
…, M Sato, K Imaizumi, A Ogawa, K Ikuyama… - European journal of …, 2010 - nature.com
Results: In the active FM group, abdominal visceral and subcutaneous fat areas significantly
(P< 0.01) decreased from baseline by an average of 4.6%(mean (confidence interval):− 5.8 (…
(P< 0.01) decreased from baseline by an average of 4.6%(mean (confidence interval):− 5.8 (…
[HTML][HTML] Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism …
T Yoneda, K Imaizumi, K Oono, D Yui, F Gomi… - Journal of Biological …, 2001 - ASBMB
When accumulation of a malfolded protein in the endoplastic reticulum (ER) is induced by
various adverse conditions, such as hypoxia, glucose starvation, and perturbation of calcium …
various adverse conditions, such as hypoxia, glucose starvation, and perturbation of calcium …
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
…, T Manabe, S Yamagishi, Y Bando, K Imaizumi… - The Journal of cell …, 2004 - rupress.org
Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could
arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been …
arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been …
Haploinsufficiency of NSD1 causes Sotos syndrome
N Kurotaki, K Imaizumi, N Harada, M Masuno… - Nature …, 2002 - nature.com
We isolated NSD1 from the 5q35 breakpoint in an individual with Sotos syndrome harboring
a chromosomal translocation. We identified 1 nonsense, 3 frameshift and 20 …
a chromosomal translocation. We identified 1 nonsense, 3 frameshift and 20 …
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
T Katayama, K Imaizumi, N Sato, K Miyoshi, T Kudo… - Nature cell …, 1999 - nature.com
… Double-labelling of PS1 (j, red) and IRE1–Flag (k, green) was observed in the ER (l, yellow)…
We thank K. Iqbal for the Tau expression vector and anti-Tau antibody; and T. Iwasaki for …
We thank K. Iqbal for the Tau expression vector and anti-Tau antibody; and T. Iwasaki for …
Endothelial–mesenchymal transition in bleomycin-induced pulmonary fibrosis
N Hashimoto, SH Phan, K Imaizumi… - American journal of …, 2010 - atsjournals.org
The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in
which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and …
which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and …