International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

…, I Liebscher, HH Lin, DC Martinelli, KR Monk… - Pharmacological …, 2015 - ASPET
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

New insights on Schwann cell development

KR Monk, ML Feltri, C Taveggia - Glia, 2015 - Wiley Online Library
In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact with
axons throughout development. Schwann cells generate the insulating myelin sheath and …

[PDF][PDF] Behaviorally consequential astrocytic regulation of neural circuits

…, X Yu, T Papouin, E Cheong, MR Freeman, KR Monk… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has shown …

AG protein–coupled receptor is essential for Schwann cells to initiate myelination

KR Monk, SG Naylor, TD Glenn, S Mercurio, JR Perlin… - Science, 2009 - science.org
The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate nervous
system. Axonal signals activate expression of specific transcription factors, including Oct6 …

[PDF][PDF] A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133

…, M Cöster, KU Simon, S Rothemund, KR Monk… - Cell reports, 2014 - cell.com
Monk,2 and Torsten Schoneberg 1,* 1Institute of Biochemistry, Medical Faculty, University
of … Genotyping of st63 and st49 was performed as previously described (Monk et al 2009). …

The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells

YB Wetherill, CE Petre, KR Monk, A Puga… - Molecular cancer …, 2002 - AACR
Abstract Treatment for prostatic adenocarcinoma is reliant on the initial androgen dependence
of this tumor type. The goal of therapy is to eliminate androgen receptor activity, either …

[PDF][PDF] The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211

…, ML Feltri, T Schöneberg, X Piao, KR Monk - Neuron, 2015 - cell.com
Monk1,5,* 1Department of Developmental Biology, Washington University School of Medicine,
St. … been previously employed to assess sorting of axons by SCs in zebrafish (eg, Monk et …

Gpr126 is essential for peripheral nerve development and myelination in mammals

KR Monk, K Oshima, S Jörs, S Heller… - …, 2011 - journals.biologists.com
In peripheral nerves, Schwann cells form the myelin sheath that insulates axons and allows
rapid propagation of action potentials. Although a number of regulators of Schwann cell …

[HTML][HTML] Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells

…, CM Hingtgen, N Ratner, KR Monk… - The Journal of …, 2003 - Am Soc Clin Investig
The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin
that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (…

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

…, B Grosshans, S Hornemann, F Bassilana, KR Monk… - Nature, 2016 - nature.com
Ablation of the cellular prion protein PrP C leads to a chronic demyelinating polyneuropathy
affecting Schwann cells. Neuron-restricted expression of PrP C prevents the disease 1 , …