Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter transcriptional
programs believed to promote long-lasting synaptic and behavioral adaptations. Here…

Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum
disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language …

CRISPR-based technology has provided new avenues to interrogate gene function, but
difficulties in transgene expression in post-mitotic neurons has delayed incorporation of these …

Genomic enhancer elements regulate gene expression programs important for neuronal fate
and function and are implicated in brain disease states. Enhancers undergo bidirectional …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

Epigenetic mechanisms such as DNA methylation are essential regulators of the function
and information storage capacity of neurons. DNA methylation is highly dynamic in the …

… KE Savell and JJ Day both conceived of the idea, wrote the manuscript, and designed the
… Picciotto MR, Wickman K. Using knockout and transgenic mice to study neurophysiology …

Loss-of-function mutations in progranulin (GRN) are a major genetic cause of
frontotemporal dementia (FTD), possibly due to loss of progranulin's neurotrophic and anti-inflammatory …

Variation in body form among human groups is structured by a blend of natural selection
driven by local climatic conditions and random genetic drift. However, attempts to test …

Blue wavelength light is used as an optical actuator in numerous optogenetic technologies
employed in neuronal systems. However, the potential side effects of blue light in neurons …