User profiles for J. Milbrandt

Jeffrey Milbrandt

James S McDonnell Professor of Genetics, Washington University
Verified email at wustl.edu
Cited by 49967

The GDNF family ligands and receptors—implications for neural development

…, H Enomoto, EM Johnson Jr, J Milbrandt - Current opinion in …, 2000 - Elsevier
… We thank all members of the Milbrandt and Johnson labs for invaluable discussions regarding
the ideas and issues presented here. The authors are supported by National Institutes of …

Lipid rafts in neuronal signaling and function

BA Tsui-Pierchala, M Encinas, J Milbrandt… - Trends in …, 2002 - cell.com
… Jeffrey Milbrandt Jeffrey Milbrandt … Liu J. …

[PDF][PDF] Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism

J Gerdts, DW Summers, J Milbrandt, A DiAntonio - Neuron, 2016 - cell.com
Wallerian axon degeneration is a form of programmed subcellular death that promotes axon
breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases, …

[PDF][PDF] Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme

…, Y Sasaki, C Wolberger, RR Townsend, J Milbrandt… - Cell metabolism, 2007 - cell.com
Intracellular nicotinamide phosphoribosyltransferase (iNampt) is an essential enzyme in the
NAD biosynthetic pathway. An extracellular form of this protein (eNampt) has been reported …

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

T Araki, Y Sasaki, J Milbrandt - Science, 2004 - science.org
Axonal degeneration is an active program of self-destruction that is observed in many
physiological and pathological settings. In Wallerian degeneration slow (wld s ) mice, Wallerian …

A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor

J Milbrandt - Science, 1987 - science.org
Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from
sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone …

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

…, JP Golden, DJ Creedon, EM Johnson Jr, J Milbrandt - Nature, 1996 - nature.com
THE normal development of the vertebrate nervous system entails the death of 30–70% of the
neurons originally generated in most neuronal populations 1 . This naturally occurring cell …

[HTML][HTML] Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRα3–RET receptor complex

…, ML Leitner, T Araki, EM Johnson, J Milbrandt - Neuron, 1998 - cell.com
The glial cell line–derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and
Persephin [PSP]) signal through a multicomponent receptor system composed of a high-…

Resveratrol stimulates AMP kinase activity in neurons

B Dasgupta, J Milbrandt - Proceedings of the National …, 2007 - National Acad Sciences
Resveratrol is a polyphenol produced by plants that has multiple beneficial activities similar
to those associated with caloric restriction (CR), such as increased life span and delay in the …

[HTML][HTML] A multimoment bulk microphysics parameterization. Part I: Analysis of the role of the spectral shape parameter

JA Milbrandt, MK Yau - Journal of the atmospheric sciences, 2005 - journals.ametsoc.org
With increasing computer power, explicit microphysics schemes are becoming increasingly
important in atmospheric models. Many schemes have followed the approach of Kessler in …