User profiles for J. R. Naegele
Janice R. NaegeleAlan M Dachs Professor of Science, Professor of Biology, Program in Neuroscience and … Verified email at wesleyan.edu Cited by 4293 |
[PDF][PDF] Fusion of regionally specified hPSC-derived organoids models human brain development and interneuron migration
…, M Zhong, EG Stanley, AG Elefanty, JR Naegele… - Cell stem cell, 2017 - cell.com
Organoid techniques provide unique platforms to model brain development and neurological
disorders. Whereas several methods for recapitulating corticogenesis have been described…
disorders. Whereas several methods for recapitulating corticogenesis have been described…
Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase
…, MJ During, P Wahle, JR Naegele - Journal of …, 1995 - Soc Neuroscience
Regional variations in the expression of a striatal enriched protein tyrosine phosphatase
called STEP were studied in the adult rat brain by a combination of immunocytochemistry, …
called STEP were studied in the adult rat brain by a combination of immunocytochemistry, …
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
MJ During, JR Naegele, KL O'Malley, AI Geller - Science, 1994 - science.org
One therapeutic approach to treating Parkinson's disease is to convert endogenous striatal
cells into levo-3,4-dihydroxyphenylalanine (L-dopa)-producing cells. A defective herpes …
cells into levo-3,4-dihydroxyphenylalanine (L-dopa)-producing cells. A defective herpes …
IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus
YS Choi, HY Cho, KR Hoyt, JR Naegele, K Obrietan - Glia, 2008 - Wiley Online Library
Adult progenitor cell proliferation in the subgranular zone (SGZ) of the dentate gyrus is a
dynamic process that is modulated by an array of physiological process, including locomotor …
dynamic process that is modulated by an array of physiological process, including locomotor …
Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy
JR Naegele, X Maisano, J Yang, S Royston… - Neuropharmacology, 2010 - Elsevier
The potential applications of stem cell therapies for treating neurological disorders are
enormous. Many laboratories are focusing on stem cell treatments for CNS diseases, including …
enormous. Many laboratories are focusing on stem cell treatments for CNS diseases, including …
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
…, S Royston, SM Tagliatela, JR Naegele… - Genes, Brain and …, 2012 - Wiley Online Library
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and
prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that …
prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that …
A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures
PJ Lombroso, JR Naegele, E Sharma… - Journal of …, 1993 - Soc Neuroscience
Immunocytochemical and biochemical studies were conducted to characterize a brain-specific
protein tyrosine phosphatase, designated STEP for striatal enriched phosphatase. STEP …
protein tyrosine phosphatase, designated STEP for striatal enriched phosphatase. STEP …
Neuroprotective strategies to avert seizure‐induced neurodegeneration in epilepsy
JR Naegele - Epilepsia, 2007 - Wiley Online Library
Neurodegeneration in limbic circuits is a hallmark feature of chronic temporal lobe epilepsy (TLE).
Studies in experimental animal models and human patients indicate that seizure‐…
Studies in experimental animal models and human patients indicate that seizure‐…
[HTML][HTML] Cortical GABAergic interneuron/progenitor transplantation as a novel therapy for intractable epilepsy
Q Zhu, JR Naegele, S Chung - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Epilepsy is a severe neurological disease affecting more than 70 million people worldwide
that is characterized by unpredictable and abnormal electrical discharges resulting in …
that is characterized by unpredictable and abnormal electrical discharges resulting in …
The postnatal development of monocular optokinetic nystagmus in infants
JR Naegele, R Held - Vision research, 1982 - Elsevier
… A preliminary report of these findings has appeared previously (Naegele JR and Held R..
1980) ARVO Annual Meeting. … Naegele was supported by grants from the Spencer Foundation …
1980) ARVO Annual Meeting. … Naegele was supported by grants from the Spencer Foundation …