User profiles for J. R. Naegele

Janice R. Naegele

Alan M Dachs Professor of Science, Professor of Biology, Program in Neuroscience and …
Verified email at wesleyan.edu
Cited by 4293

[PDF][PDF] Fusion of regionally specified hPSC-derived organoids models human brain development and interneuron migration

…, M Zhong, EG Stanley, AG Elefanty, JR Naegele… - Cell stem cell, 2017 - cell.com
Organoid techniques provide unique platforms to model brain development and neurological
disorders. Whereas several methods for recapitulating corticogenesis have been described…

Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase

…, MJ During, P Wahle, JR Naegele - Journal of …, 1995 - Soc Neuroscience
Regional variations in the expression of a striatal enriched protein tyrosine phosphatase
called STEP were studied in the adult rat brain by a combination of immunocytochemistry, …

Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase

MJ During, JR Naegele, KL O'Malley, AI Geller - Science, 1994 - science.org
One therapeutic approach to treating Parkinson's disease is to convert endogenous striatal
cells into levo-3,4-dihydroxyphenylalanine (L-dopa)-producing cells. A defective herpes …

IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus

YS Choi, HY Cho, KR Hoyt, JR Naegele, K Obrietan - Glia, 2008 - Wiley Online Library
Adult progenitor cell proliferation in the subgranular zone (SGZ) of the dentate gyrus is a
dynamic process that is modulated by an array of physiological process, including locomotor …

Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy

JR Naegele, X Maisano, J Yang, S Royston… - Neuropharmacology, 2010 - Elsevier
The potential applications of stem cell therapies for treating neurological disorders are
enormous. Many laboratories are focusing on stem cell treatments for CNS diseases, including …

Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model

…, S Royston, SM Tagliatela, JR Naegele… - Genes, Brain and …, 2012 - Wiley Online Library
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and
prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that …

A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures

PJ Lombroso, JR Naegele, E Sharma… - Journal of …, 1993 - Soc Neuroscience
Immunocytochemical and biochemical studies were conducted to characterize a brain-specific
protein tyrosine phosphatase, designated STEP for striatal enriched phosphatase. STEP …

Neuroprotective strategies to avert seizure‐induced neurodegeneration in epilepsy

JR Naegele - Epilepsia, 2007 - Wiley Online Library
Neurodegeneration in limbic circuits is a hallmark feature of chronic temporal lobe epilepsy (TLE).
Studies in experimental animal models and human patients indicate that seizure‐…

[HTML][HTML] Cortical GABAergic interneuron/progenitor transplantation as a novel therapy for intractable epilepsy

Q Zhu, JR Naegele, S Chung - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Epilepsy is a severe neurological disease affecting more than 70 million people worldwide
that is characterized by unpredictable and abnormal electrical discharges resulting in …

The postnatal development of monocular optokinetic nystagmus in infants

JR Naegele, R Held - Vision research, 1982 - Elsevier
… A preliminary report of these findings has appeared previously (Naegele JR and Held R..
1980) ARVO Annual Meeting. … Naegele was supported by grants from the Spencer Foundation …