Microglia in Alzheimer's disease
Proliferation and activation of microglia in the brain, concentrated around amyloid plaques,
is a prominent feature of Alzheimer’s disease (AD). Human genetics data point to a key role …
is a prominent feature of Alzheimer’s disease (AD). Human genetics data point to a key role …
Power and performance management of virtualized computing environments via lookahead control
There is growing incentive to reduce the power consumed by large-scale data centers that
host online services such as banking, retail commerce, and gaming. Virtualization is a …
host online services such as banking, retail commerce, and gaming. Virtualization is a …
Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray …
NK Sauter, JE Hanson, GD Glick, JH Brown… - Biochemistry, 1992 - ACS Publications
Revised Manuscript Received July 22, 1992 abstract: The interaction between influenza
virus hemagglutinin and its cell-surface receptor, 5-N-acetylneuraminic acid (sialic acid), was …
virus hemagglutinin and its cell-surface receptor, 5-N-acetylneuraminic acid (sialic acid), was …
Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance …
…, MD Bednarski, BA Wurzburg, JE Hanson… - Biochemistry, 1989 - ACS Publications
Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, and
Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138, and …
Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138, and …
An architectural approach to autonomic computing
SR White, JE Hanson, I Whalley… - International …, 2004 - ieeexplore.ieee.org
We describe an architectural approach to achieving the goals of autonomic computing. The
architecture that we outline describes interfaces and behavioral requirements for individual …
architecture that we outline describes interfaces and behavioral requirements for individual …
[PDF][PDF] Agent-human interactions in the continuous double auction
The Continuous Double Auction (CDA) is the dominant market institution for real-world trading
of equities, commodities, derivatives, etc. We describe a series of laboratory experiments …
of equities, commodities, derivatives, etc. We describe a series of laboratory experiments …
[PDF][PDF] Changes in the synaptic proteome in tauopathy and rescue of tau-induced synapse loss by C1q antibodies
…, B Chih, J Klumperman, C Bakalarski, JE Hanson… - Neuron, 2018 - cell.com
Synapse loss and Tau pathology are hallmarks of Alzheimer's disease (AD) and other
tauopathies, but how Tau pathology causes synapse loss is unclear. We used unbiased proteomic …
tauopathies, but how Tau pathology causes synapse loss is unclear. We used unbiased proteomic …
[PDF][PDF] Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy
Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration
Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), but how …
diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), but how …
Dynamic pricing by software agents
We envision a future in which the global economy and the Internet will merge, evolving into
an information economy bustling with billions of economically motivated software agents that …
an information economy bustling with billions of economically motivated software agents that …