User profiles for H. Tanila

Heikki Tanila

Verified email at uef.fi
Cited by 19017

[HTML][HTML] The hippocampus, memory, and place cells: is it spatial memory or a memory space?

…, P Dudchenko, E Wood, M Shapiro, H Tanila - Neuron, 1999 - cell.com
Identifying the scope and nature of memory processing by the hippocampus has proved a
formidable challenge. The major initial insights came from studies of amnesia in human …

Neurocognitive aging: prior memories hinder new hippocampal encoding

IA Wilson, M Gallagher, H Eichenbaum, H Tanila - Trends in neurosciences, 2006 - cell.com
Normal aging is often accompanied by impairments in forming new memories, and studies
of aging rodents have revealed structural and functional changes to the hippocampus that …

[HTML][HTML] Altered insulin signaling in Alzheimer's disease brain–special emphasis on PI3K-Akt pathway

…, S Kemppainen, H Martiskainen, H Tanila… - Frontiers in …, 2019 - frontiersin.org
Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin …

Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy

…, T Harkany, A Pitkänen, H Tanila - Journal of …, 2009 - Soc Neuroscience
h, and subsequently cryoprotected in a solution composed of 20% glycerol in 0.02 m K-PBS,
pH 7.4, for 24 h … ), and immunoreactivity was visualized with H 2 O 2 and nickel-enhanced 3,…

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

…, L Broersen, D Lütjohann, T Hartmann, H Tanila - Neurobiology of …, 2006 - Elsevier
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide
(Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and …

Role of α-synuclein in presynaptic dopamine recruitment

L Yavich, H Tanila, S Vepsäläinen… - Journal of …, 2004 - Soc Neuroscience
… Amplification of the human α-syn transgene fragment yielded the PCR product only in the
h + m + samples. Additionally, amplification of either genomic DNA fragment of mouse …

Cues that hippocampal place cells encode: dynamic and hierarchical representation of local and distal stimuli

ML Shapiro, H Tanila, H Eichenbaum - Hippocampus, 1997 - Wiley Online Library
… If no unit activity was observed during a 5- to 10-min trial, the electrodes were advanced
20–30 m and the rat was returned to its home cage for at least 4 h to allow the brain tissue to …

Increased fMRI responses during encoding in mild cognitive impairment

A Hämäläinen, M Pihlajamäki, H Tanila… - Neurobiology of …, 2007 - Elsevier
Structural and functional magnetic resonance imaging (fMRI) was performed on 21 healthy
elderly controls, 14 subjects with mild cognitive impairment (MCI) and 15 patients with mild …

Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study

M Pihlajamäki, H Tanila, T Hänninen… - Annals of Neurology …, 2000 - Wiley Online Library
… Braak H, Braak E. Evolution of the neuropathology of Alzheimer’s disease. Acta Neurol Scand
… Damasio H. Human brain anatomy in computerized images. New York: Oxford University …

Age-associated alterations of hippocampal place cells are subregion specific

…, M Gallagher, H Eichenbaum, H Tanila - Journal of …, 2005 - Soc Neuroscience
Aging is associated with spatial memory impairments and with deficient encoding of
information by the hippocampus. In young adult rats, recent studies on the firing properties of …