User profiles for H. Hirata

Hiromi Hirata

Aoyama Gakuin University
Verified email at chem.aoyama.ac.jp
Cited by 4720

[HTML][HTML] Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

H Kamata, S Honda, S Maeda, L Chang, H Hirata… - Cell, 2005 - cell.com
… Indeed, flow cytometric analysis of cells incubated with the H 2 O 2 -sensitive fluorescent
dye, CM-H 2 DCFDA, confirmed substantial accumulation of H 2 O 2 in RelA- and IKKβ-…

Redox regulation of cellular signalling

H Kamata, H Hirata - Cellular signalling, 1999 - Elsevier
… converts O 2 − into H 2 O 2 , and then H 2 O 2 is mostly degraded to H 2 O by glutathione (…
(TRX) has H 2 O 2 reducing activity as well as a function in refolding oxidised proteins. H 2 O 2 …

Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop

H Hirata, S Yoshiura, T Ohtsuka, Y Bessho, T Harada… - Science, 2002 - science.org
Transcription of messenger RNAs (mRNAs) for Notch signaling molecules oscillates with 2-hour
cycles, and this oscillation is important for coordinated somite segmentation. However, …

[HTML][HTML] XR (extended reality: virtual reality, augmented reality, mixed reality) technology in spine medicine: status quo and quo vadis

T Morimoto, T Kobayashi, H Hirata, K Otani… - Journal of Clinical …, 2022 - mdpi.com
… Beyond the improvement of anatomical knowledge, other advantages of XR technology
that use 3D holograms for medical student anatomy education include 24 h free access and …

Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

Y Bessho, H Hirata, Y Masamizu… - Genes & …, 2003 - genesdev.cshlp.org
Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the
presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a …

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis

H Hirata, A Takahashi, S Kobayashi… - The Journal of …, 1998 - rupress.org
Two novel synthetic tetrapeptides, VEID-CHO and DMQD-CHO, could selectively inhibit
caspase-6 and caspase-3, respectively. We used these inhibitors to dissect the pathway of …

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

…, RF Place, D Pookot, S Basak, JM Whitson, H Hirata… - Oncogene, 2009 - nature.com
Histone deacetylases (HDACs) are frequently overexpressed in broad range of cancer types,
where they alter cellular epigenetic programming to promote cell proliferation and survival. …

[PDF][PDF] Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling

…, C Watanabe, I Lee, X Wang, W Shi, H Araki, H Hirata… - Immunity, 2000 - cell.com
We have identified the lymphocyte semaphorin CD100/Sema4D as a CD40-inducible
molecule by subtractive cDNA cloning. CD100 stimulation significantly enhanced the effects of …

Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205

H Hirata, Y Hinoda, V Shahryari, G Deng, K Nakajima… - Cancer research, 2015 - AACR
Recently, long noncoding RNAs (lncRNA) have emerged as new gene regulators and
prognostic markers in several cancers, including renal cell carcinoma (RCC). In this study, we …

[HTML][HTML] Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A

…, V Verdier, R Koebnik, JM Dow, RP Ryan, H Hirata… - BMC genomics, 2008 - Springer
Background Xanthomonas oryzae pv. oryzae causes bacterial blight of rice (Oryza sativa L.),
a major disease that constrains production of this staple crop in many parts of the world. We …