User profiles for G. Hilgen
Dr Gerrit HilgenAssociate Professor, Health & Life Sciences, Northumbria University, UK Verified email at northumbria.ac.uk Cited by 1130 |
[HTML][HTML] Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
… Schematic representation of alternative splice variants of the E1A reporter (e) and denaturing
PAGE and autoradiography using a phosphoimager (f), n = 3; g Northern blot analysis …
PAGE and autoradiography using a phosphoimager (f), n = 3; g Northern blot analysis …
Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency
… (E–G): Higher magnifications of recover in expressing photoreceptors and their morphology
(Recov, red) including putative outer segments and axon terminals. (H): Photoreceptor outer …
(Recov, red) including putative outer segments and axon terminals. (H): Photoreceptor outer …
[HTML][HTML] Next generation organoid engineering to replace animals in cancer drug testing
… Dormancy, or G 0 cell cycle arrest, and its contribution to treatment resistance is also well
known. In the dormant state, also known as quiescence, cancer cells accumulate additional …
known. In the dormant state, also known as quiescence, cancer cells accumulate additional …
[PDF][PDF] Unsupervised spike sorting for large-scale, high-density multielectrode arrays
We present a method for automated spike sorting for recordings with high-density, large-scale
multielectrode arrays. Exploiting the dense sampling of single neurons by multiple …
multielectrode arrays. Exploiting the dense sampling of single neurons by multiple …
Systematic comparison of retinal organoid differentiation from human pluripotent stem cells reveals stage specific, cell line, and methodological differences
A<sc>bstract</sc> A major goal in the stem cell field is to generate tissues that can be utilized
as a universal tool for in vitro models of development and disease, drug development, or …
as a universal tool for in vitro models of development and disease, drug development, or …
[HTML][HTML] Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light …
… The DMMB reagent was prepared as follows: 16 mg DMMB in 1 L double-distilled water
containing 3.04 g glycine, 1.6 g NaCl and 95 ml of 0.1 M Acetic Acid. The pH of the solution was …
containing 3.04 g glycine, 1.6 g NaCl and 95 ml of 0.1 M Acetic Acid. The pH of the solution was …
Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line-and method-dependent
Induced pluripotent stem cell (iPSC)-derived retinal organoids provide a platform to study
human retinogenesis, disease modeling, and compound screening. Although retinal organoids …
human retinogenesis, disease modeling, and compound screening. Although retinal organoids …
Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration
Retinal dystrophies often lead to blindness. Developing therapeutic interventions to restore
vision is therefore of paramount importance. Here we demonstrate the ability of pluripotent …
vision is therefore of paramount importance. Here we demonstrate the ability of pluripotent …
Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
Microglia are the primary resident immune cells in the retina. They regulate neuronal survival
and synaptic pruning making them essential for normal development. Following injury, they …
and synaptic pruning making them essential for normal development. Following injury, they …
Human retinal organoids provide a suitable tool for toxicological investigations: a comprehensive validation using drugs and compounds affecting the retina
… • Intraperitoneal: 4 k/kg followed by 2 doses of 2 g/kg after 24 h and 48 h respectively … •
Intraperitoneal: 4 k/kg followed by 2 doses of 2 g/kg after 24 h and 48 h respectively …
Intraperitoneal: 4 k/kg followed by 2 doses of 2 g/kg after 24 h and 48 h respectively …