Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Synaptic plasticity in the autoassociative network of recurrent connections among hippocampal
CA3 pyramidal cells is thought to enable the storage of episodic memory. Impaired …

There is considerable evidence showing that the neurodegenerative processes that lead to
sporadic Parkinson's disease (PD) begin many years before the appearance of the …

INTRODUCTION During development, brain circuits go through phases of synapse formation,
stabilization, or elimination. γ-aminobutyric acid–mediated (GABAergic) synapse formation …

Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory dysfunction in
early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42 )-based model of early AD, we now …

… to occur for the formation of mutated ataxin-3 aggregates (Gonçalves et al. 2013). To this
end, we … FQ and JR contributed to the electrophysiogical experiments in A 2A R KO mice. JR …

Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A 2A
receptors (A 2A R) are mostly located in synapses controlling synaptic plasticity. The over-…

Background Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a
degenerative disease characterized by the loss of retinal ganglion cells (RGCs). There is clinical …

The increased healthspan afforded by coffee intake provides novel opportunities to identify
new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine …

Neurodegeneration is a process transversal to neuropsychiatric diseases and the understanding
of its mechanisms should allow devising strategies to prevent this irreversible step in …