User profiles for E. D. Herzog

Erik Herzog

Professor of Biology, Washington University
Verified email at wustl.edu
Cited by 14129

Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons

…, CS Colwell, AJ Harmar, J Waschek, ED Herzog - Nature …, 2005 - nature.com
The mammalian suprachiasmatic nucleus (SCN) is a master circadian pacemaker. It is not
known which SCN neurons are autonomous pacemakers or how they synchronize their daily …

A circadian clock in macrophages controls inflammatory immune responses

…, U Abraham, GD Eom, ED Herzog… - Proceedings of the …, 2009 - National Acad Sciences
Time of day-dependent variations of immune system parameters are ubiquitous phenomena
in immunology. The circadian clock has been attributed with coordinating these variations …

Circadian rhythms in isolated brain regions

M Abe, ED Herzog, S Yamazaki… - Journal of …, 2002 - Soc Neuroscience
The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus has been referred to
as the master circadian pacemaker that drives daily rhythms in behavior and physiology. …

[PDF][PDF] Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH

…, N Rensing, P Cliften, DF Wozniak, ED Herzog… - Cell metabolism, 2013 - cell.com
The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic regulation. However,
the role of Sirt1 in the regulation of aging and longevity is still controversial. Here we …

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

ED Herzog, JS Takahashi, GD Block - Nature neuroscience, 1998 - nature.com
The suprachiasmatic nucleus (SCN) is the master circadian pacemaker in mammals, and one
molecular regulator of circadian rhythms is the Clock gene. Here we studied the discharge …

[HTML][HTML] Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

…, JT Dearborn, JP Culver, ED Herzog… - The Journal of …, 2013 - Am Soc Clin Investig
Brain aging is associated with diminished circadian clock output and decreased expression
of the core clock proteins, which regulate many aspects of cellular biochemistry and …

Neurons and networks in daily rhythms

ED Herzog - Nature Reviews Neuroscience, 2007 - nature.com
Biological pacemakers dictate our daily schedules in physiology and behaviour. The molecules,
cells and networks that underlie these circadian rhythms can now be monitored using …

[PDF][PDF] Come together, right… now: synchronization of rhythms in a mammalian circadian clock

SJ Aton, ED Herzog - Neuron, 2005 - cell.com
In mammals, the suprachiasmatic nuclei (SCN) of the hypothalamus act as a dominant
circadian pacemaker, coordinating rhythms throughout the body and regulating daily and …

Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons

ED Herzog, SJ Aton, R Numano… - Journal of biological …, 2004 - journals.sagepub.com
The mammalian SCN contains a biological clock that drives remarkably precise circadian
rhythms in vivo and in vitro. This study asks whether the cycle-to-cycle variability of behavioral …

Circadian rhythm generation and entrainment in astrocytes

LM Prolo, JS Takahashi, ED Herzog - Journal of Neuroscience, 2005 - Soc Neuroscience
In mammals, the master circadian pacemaker is considered the suprachiasmatic nucleus (SCN)
of the hypothalamus. The SCN consists of a heterogeneous population of neurons and …