… a carbon fiber electrode placed inside a patch electrode used in whole cell mode, to
measure cytosolic catecholamine levels in chromaffin cells and neurons (Mosharov and Sulzer, …

Parkinson's disease arises from genetic and possibly neurotoxic causes that produce massive
cell death of the neuromelanin-containing dopaminergic neurons of the substantia nigra. …

… The Sulzer lab’s work on addiction and basal ganglia function is supported by the NIDA,
NIAA, NINDS, and the Simons, Parkinson’s Disease, and Michael J. Fox Foundations. Thanks to …

α-Synuclein (α-Syn) is a 14 kDa protein of unknown function that has been implicated in the
pathophysiology of Parkinson's disease (PD). Here, we show that α-Syn −/− mice are viable …

… (D) Effect of a 2 M excess of glyceraldehyde-3-phosphate-dehydrogenase (GAPDH),
ribonuclease A (RNase A), or ovalbumin (Ovalb) (23) in the lysosomal binding and uptake of α-…

… Pothos and D. Sulzer, unpublished observations). Recording media contained 150 mM
NaCl, 4.2 mM KCI, 1 .O mM NaH,PO,, 11.2 mM glucose, 0.7 mM MgCl,, 2 mM CaCl,, 10 mM …

Developmental alterations of excitatory synapses are implicated in autism spectrum disorders
(ASDs). Here, we report increased dendritic spine density with reduced developmental …

Altered degradation of α-synuclein (α-syn) has been implicated in the pathogenesis of
Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone-mediated …

… (d) Contribution of macroautophagy calculated as percentage of protein degradation sensitive
to 3-methyladenine (3-MA). (e) Degradation of long-lived proteins in striatal cells from wild-…

… –F) In the neocortex, dark-field microscopy of emulsion autoradiographs shows expression
of VGLUT3 (D) by multiple layers, but most strongly by layer II. In contrast, VGLUT1 antisense …