User profiles for D. Kacy Cullen

D. Kacy Cullen

Associate Professor of Neurosurgery & Bioengineering, University of Pennsylvania
Verified email at mail.med.upenn.edu
Cited by 5930

Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges

…, AS Kochar, SE Mackinnon, DK Cullen - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Damage to the peripheral nervous system is surprisingly common and occurs primarily from
trauma or a complication of surgery. Although recovery of nerve function occurs in many …

High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model

MC LaPlaca, DK Cullen, JJ McLoughlin… - Journal of …, 2005 - Elsevier
The fidelity of cell culture simulations of traumatic brain injury (TBI) that yield tolerance and
mechanistic information relies on both the cellular models and mechanical insult parameters. …

Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal–astrocytic co-cultures

DK Cullen, CM Simon, MC LaPlaca - Brain research, 2007 - Elsevier
A mechanical insult to the brain drastically alters the microenvironment as specific cell types
become reactive in an effort to sequester severely damaged tissue. Although injury-induced …

Two-Dimensional Ti3C2 MXene for High-Resolution Neural Interfaces

…, O Adewole, P Lelyukh, L Escobedo, DK Cullen… - Acs Nano, 2018 - ACS Publications
High-resolution neural interfaces are essential tools for studying and modulating neural
circuits underlying brain function and disease. Because electrodes are miniaturized to achieve …

Animal models of traumatic brain injury

VE Johnson, DF Meaney, DK Cullen… - Handbook of clinical …, 2015 - Elsevier
Traumatic brain injury (TBI) is a major health issue comprising a heterogeneous and complex
array of pathologies. Over the last several decades, numerous animal models have been …

Mechanical disruption of the blood–brain barrier following experimental concussion

VE Johnson, MT Weber, R Xiao, DK Cullen… - Acta …, 2018 - Springer
Although concussion is now recognized as a major health issue, its non-lethal nature has
limited characterization of the underlying pathophysiology. In particular, potential …

Injectable and conductive granular hydrogels for 3D printing and electroactive tissue support

M Shin, KH Song, JC Burrell, DK Cullen… - Advanced …, 2019 - Wiley Online Library
Conductive hydrogels are attractive to mimic electrophysiological environments of biological
tissues and toward therapeutic applications. Injectable and conductive hydrogels are of …

A porcine model of traumatic brain injury via head rotational acceleration

DK Cullen, JP Harris, KD Browne, JA Wolf… - Injury models of the …, 2016 - Springer
Unique from other brain disorders, traumatic brain injury (TBI) generally results from a
discrete biomechanical event that induces rapid head movement. The large size and high …

Developing a tissue-engineered neural-electrical relay using encapsulated neuronal constructs on conducting polymer fibers

DK Cullen, AR Patel, JF Doorish… - Journal of neural …, 2008 - iopscience.iop.org
Neural-electrical interface platforms are being developed to extracellularly monitor neuronal
population activity. Polyaniline-based electrically conducting polymer fibers are attractive …

Three-dimensional neural constructs: a novel platform for neurophysiological investigation

HR Irons, DK Cullen, NP Shapiro… - Journal of neural …, 2008 - iopscience.iop.org
Morphological and electrophysiological properties of neural cells are substantially influenced
by their immediate extracellular surroundings, yet the features of this environment are …