User profiles for D. Kacy Cullen
D. Kacy CullenAssociate Professor of Neurosurgery & Bioengineering, University of Pennsylvania Verified email at mail.med.upenn.edu Cited by 5930 |
Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges
Damage to the peripheral nervous system is surprisingly common and occurs primarily from
trauma or a complication of surgery. Although recovery of nerve function occurs in many …
trauma or a complication of surgery. Although recovery of nerve function occurs in many …
High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model
MC LaPlaca, DK Cullen, JJ McLoughlin… - Journal of …, 2005 - Elsevier
The fidelity of cell culture simulations of traumatic brain injury (TBI) that yield tolerance and
mechanistic information relies on both the cellular models and mechanical insult parameters. …
mechanistic information relies on both the cellular models and mechanical insult parameters. …
Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal–astrocytic co-cultures
DK Cullen, CM Simon, MC LaPlaca - Brain research, 2007 - Elsevier
A mechanical insult to the brain drastically alters the microenvironment as specific cell types
become reactive in an effort to sequester severely damaged tissue. Although injury-induced …
become reactive in an effort to sequester severely damaged tissue. Although injury-induced …
Two-Dimensional Ti3C2 MXene for High-Resolution Neural Interfaces
High-resolution neural interfaces are essential tools for studying and modulating neural
circuits underlying brain function and disease. Because electrodes are miniaturized to achieve …
circuits underlying brain function and disease. Because electrodes are miniaturized to achieve …
Animal models of traumatic brain injury
Traumatic brain injury (TBI) is a major health issue comprising a heterogeneous and complex
array of pathologies. Over the last several decades, numerous animal models have been …
array of pathologies. Over the last several decades, numerous animal models have been …
Mechanical disruption of the blood–brain barrier following experimental concussion
VE Johnson, MT Weber, R Xiao, DK Cullen… - Acta …, 2018 - Springer
Although concussion is now recognized as a major health issue, its non-lethal nature has
limited characterization of the underlying pathophysiology. In particular, potential …
limited characterization of the underlying pathophysiology. In particular, potential …
Injectable and conductive granular hydrogels for 3D printing and electroactive tissue support
Conductive hydrogels are attractive to mimic electrophysiological environments of biological
tissues and toward therapeutic applications. Injectable and conductive hydrogels are of …
tissues and toward therapeutic applications. Injectable and conductive hydrogels are of …
A porcine model of traumatic brain injury via head rotational acceleration
Unique from other brain disorders, traumatic brain injury (TBI) generally results from a
discrete biomechanical event that induces rapid head movement. The large size and high …
discrete biomechanical event that induces rapid head movement. The large size and high …
Developing a tissue-engineered neural-electrical relay using encapsulated neuronal constructs on conducting polymer fibers
DK Cullen, AR Patel, JF Doorish… - Journal of neural …, 2008 - iopscience.iop.org
Neural-electrical interface platforms are being developed to extracellularly monitor neuronal
population activity. Polyaniline-based electrically conducting polymer fibers are attractive …
population activity. Polyaniline-based electrically conducting polymer fibers are attractive …
Three-dimensional neural constructs: a novel platform for neurophysiological investigation
HR Irons, DK Cullen, NP Shapiro… - Journal of neural …, 2008 - iopscience.iop.org
Morphological and electrophysiological properties of neural cells are substantially influenced
by their immediate extracellular surroundings, yet the features of this environment are …
by their immediate extracellular surroundings, yet the features of this environment are …