… the access of substrate water to the Mn 4 CaO 5 cluster, mutation of D1-V185 has the potential
to alter the interactions of water around the Mn 4 CaO 5 cluster notably the essential Cl – …

Despite numerous studies examining the mechanisms of operant conditioning (OC), the
diversity of OC plasticity loci and their synergism have not been examined sufficiently. In the well…

A major challenge in neuroscience is to develop effective tools that infer the circuit
connectivity from large-scale recordings of neuronal activity patterns. In this study, context tree …

Many neurons exhibit regular firing that is limited to the duration and intensity of depolarizing
stimuli. However, some neurons exhibit all-or-nothing plateau potentials that, once elicited, …

Background The analyses of neuronal circuits require high-throughput technologies for
stimulating and recording many neurons simultaneously with single-neuron precision. Voltage-…

A key issue in neuroscience is understanding the ways in which neuromodulators such as
dopamine modify neuronal activity to mediate selection of distinct motor patterns. We …

In order to understand modifications in a neural network due to learning, it is paramount to
develop an effective tool that is capable of mapping the circuit connectivity and its changes …

Objective. Accurate inference of functional connectivity is critical for understanding brain
function. Previous methods have limited ability distinguishing between direct and indirect …

Dopamine (DA) is a ubiquitous neuromodulator of neuronal networks in the animal kingdom
and has a well-established role in modulating motor behavior and encoding reward …

Some neurons express a plateau of spike activity greatly outlasting a stimulus, whereas
others do not. This difference could be due to differential expression of ion channels (eg, …