A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects

…, CC Lapish, CL Czachowski… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Front‐loading is a drinking pattern in which alcohol intake is skewed toward the onset of
reward access. This phenomenon has been reported across several different alcohol self‐…

Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self‐administration

…, LM Diaz, HH Samson, CL Czachowski… - Alcoholism: Clinical …, 2003 - Wiley Online Library
… After approximately 4 weeks, we switched both groups of rats to a reinforcement schedule
used by Czachowski and Samson (1999), in which the response requirement increased …

Effects of raclopride in the nucleus accumbens on ethanol seeking and consumption

CL Czachowski, AM Chappell… - Alcoholism: Clinical …, 2001 - Wiley Online Library
Background: Nucleus accumbens dopamine has been shown to play a role in the processing
of behaviorally relevant stimuli and to mediate ethanol‐reinforced responding. Previous …

Effects of acamprosate on ethanol‐seeking and self‐administration in the rat

CL Czachowski, BH Legg… - Alcoholism: Clinical and …, 2001 - Wiley Online Library
Background: Acamprosate (calcium acetyl homotaurinate) has been used clinically to treat
relapse in alcoholics. In rats, it has been shown to decrease ethanol, but not water, self‐…

Separate measures of ethanol seeking and drinking in the rat: effects of remoxipride

CL Czachowski, LA Santini, BH Legg, HH Samson - Alcohol, 2002 - Elsevier
Remoxipride, a dopamine D 2 antagonist, decreases responding that results in the presentation
of small amounts (~0.1 ml) of ethanol in limited-access paradigms. This type of operant …

Effects of Prazosin, an α1‐Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol‐Preferring (P) Rats

…, JC Froehlich, CL Czachowski - Alcoholism: Clinical …, 2012 - Wiley Online Library
Background: Previous studies show that prazosin, an α 1 ‐adrenergic receptor antagonist,
decreases alcohol drinking in animal models of alcohol use and dependence [Rasmussen et …

Behavioral measures of alcohol self-administration and intake control: rodent models

HH Samson, CL Czachowski - 2003 - Elsevier
… In one of the original reports using this procedure (Czachowski and Samson, 1999), we
observed breakpoints averaging 125 lever-presses and ethanol intakes of 0.95 g/kg. Also, the …

Effect of operant self‐administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens

…, VS Ramachandra, CL Czachowski… - Journal of …, 2005 - Wiley Online Library
Although operant ethanol self‐administration can increase accumbal dopamine activity, the
relationship between dopamine and ethanol levels during consumption remains unclear. We …

Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats

CL Czachowski, MJ DeLory - Psychopharmacology, 2009 - Springer
… Our previous study using a similar operant model, nondependent rats, and 2 days of
acamprosate treatment at the same doses used in this study (Czachowski et al. 2001b) found that …

A new assessment of the ability of oral ethanol to function as a reinforcing stimulus

HH Samson, CL Czachowski… - Alcoholism: Clinical and …, 2000 - Wiley Online Library
Background: In animal studies, the ability of ethanol to function as a reinforcer has been
described as weak to moderate. This is in contrast with the human condition, where the …