User profiles for C. J. Ek

Joakim Ek

Fysiologi, Göteborgs Universitet
Verified email at neuro.gu.se
Cited by 3442

Barriers in the developing brain and Neurotoxicology

CJ Ek, KM Dziegielewska, MD Habgood, NR Saunders - Neurotoxicology, 2012 - Elsevier
The brain develops and grows within a well-controlled internal environment that is provided
by cellular exchange mechanisms in the interfaces between blood, cerebrospinal fluid and …

Barriers in the brain: a renaissance?

NR Saunders, CJ Ek, MD Habgood… - Trends in …, 2008 - cell.com
Barrier mechanisms regulate the exchange of molecules between the brain's internal milieu
and the rest of the body. Correct functioning of these mechanisms is critical for normal brain …

Changes in blood–brain barrier permeability to large and small molecules following traumatic brain injury in mice

…, N Bye, KM Dziegielewska, CJ Ek… - European Journal of …, 2007 - Wiley Online Library
The entry of therapeutic compounds into the brain and spinal cord is normally restricted by
barrier mechanisms in cerebral blood vessels (blood–brain barrier) and choroid plexuses (…

Immune responses in perinatal brain injury

JCY Lai, E Rocha-Ferreira, CJ Ek, X Wang… - Brain, behavior, and …, 2017 - Elsevier
The perinatal period has often been described as immune deficient. However, it has become
clear that immune responses in the neonate following exposure to microbes or as a result …

[HTML][HTML] Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair?

A Baburamani, CJ Ek, DW Walker… - Frontiers in …, 2012 - frontiersin.org
As clinicians attempt to understand the underlying reasons for the vulnerability of different
regions of the developing brain to injury, it is apparent that little is known as to how hypoxia-…

Long‐term changes in blood–brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat

HB Stolp, KM Dziegielewska, CJ Ek… - European Journal of …, 2005 - Wiley Online Library
Epidemiological evidence in human fetuses links inflammation during development with white
matter damage. Breakdown of the blood–brain barrier has been proposed as a possible …

Functional effectiveness of the blood‐brain barrier to small water‐soluble molecules in developing and adult opossum (Monodelphis domestica)

CJ Ek, KM Dziegielewska, H Stolp… - Journal of …, 2006 - Wiley Online Library
We have evaluated a small water‐soluble molecule, biotin ethylenediamine (BED, 286 Da),
as a permeability tracer across the blood‐brain barrier. This molecule was found to have …

Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia

CJ Ek, B D'angelo, AA Baburamani… - Journal of Cerebral …, 2015 - journals.sagepub.com
Insults to the developing brain often result in irreparable damage resulting in long-term
deficits in motor and cognitive functions. The only treatment today for hypoxic-ischemic …

Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat

CJ Ek, A Wong, SA Liddelow, PA Johansson… - Toxicology letters, 2010 - Elsevier
Proteins of the ATP-binding cassette (ABC) family, present at the blood–brain barrier interfaces,
have been shown to reduce the entry of compounds from blood into the brain by active …

[HTML][HTML] Spatio-temporal progression of grey and white matter damage following contusion injury in rat spinal cord

CJ Ek, MD Habgood, JK Callaway, R Dennis… - PloS one, 2010 - journals.plos.org
Cellular mechanisms of secondary damage progression following spinal cord injury remain
unclear. We have studied the extent of tissue damage from 15 min to 10 weeks after injury …