… ) to highly complex (eg, Collaborative Cross [CC] genetic reference panel, > 50 million
variants), with the genomes of the CC mice matching or exceeding the genetic diversity present in …

Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-associated
pathology are said to be ‘resilient' to AD. Identifying mechanisms underlying …

The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …

We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse
brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We …

Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits
were exposed in a subset (30%) of middle-aged mice that performed below criterion on a …

Accumulations of β-amyloid (Aβ) contribute to neurological deficits associated with Alzheimer's
disease (AD). The effects of Aβ on basal neuronal excitability and learning-related AHP …

Alzheimer’s disease (AD), the most common form of dementia in the elderly, has no cure.
Thus, the identification of key molecular mediators of cognitive decline in AD remains a top …

A successful unified pharmacophore/receptor model which has guided the synthesis of
subtype selective compounds is reviewed in light of recent developments both in ligand …