Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins,
the C-terminal SOCS box has now been identified in more than 40 proteins in nine different …

Members of the SOCS (suppressor of cytokine signalling) family of proteins play key roles in
the negative regulation of cytokine signal transduction. A series of elegant biochemical and …

The mitochondrial caspase cascade was originally thought to be required for apoptotic
death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several ‘non-…

Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing.
Despite much speculation, the factors determining their life span in the circulation are …

Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they
are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the …

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors
of several cytokine signal transduction pathways. Their expression is induced by cytokine …

INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling …

The immune system must distinguish viable cells from cells damaged by physical and infective
processes. The damaged cell-recognition molecule Clec9A is expressed on the surface …

Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense
but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the …