User profiles for B. T. Kile
Benjamin T. KileGarvan Institute of Medical Research Verified email at garvan.org.au Cited by 13833 |
The SOCS box: a tale of destruction and degradation
Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins,
the C-terminal SOCS box has now been identified in more than 40 proteins in nine different …
the C-terminal SOCS box has now been identified in more than 40 proteins in nine different …
The suppressors of cytokine signalling (SOCS)
BT Kile, WS Alexander - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Members of the SOCS (suppressor of cytokine signalling) family of proteins play key roles in
the negative regulation of cytokine signal transduction. A series of elegant biochemical and …
the negative regulation of cytokine signal transduction. A series of elegant biochemical and …
Apoptotic caspases: multiple or mistaken identities?
K McArthur, BT Kile - Trends in cell biology, 2018 - cell.com
The mitochondrial caspase cascade was originally thought to be required for apoptotic
death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several ‘non-…
death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several ‘non-…
[HTML][HTML] Programmed anuclear cell death delimits platelet life span
Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing.
Despite much speculation, the factors determining their life span in the circulation are …
Despite much speculation, the factors determining their life span in the circulation are …
[PDF][PDF] Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production
Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they
are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the …
are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the …
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
…, R Richardson, G Hausmann, BT Kile… - Proceedings of the …, 1999 - National Acad Sciences
The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors
of several cytokine signal transduction pathways. Their expression is induced by cytokine …
of several cytokine signal transduction pathways. Their expression is induced by cytokine …
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …
[PDF][PDF] Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically
Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling …
many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling …
[HTML][HTML] The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments
…, MF van Delft, J Lu, LA O'Reilly, EC Josefsson, BT Kile… - Immunity, 2012 - cell.com
The immune system must distinguish viable cells from cells damaged by physical and infective
processes. The damaged cell-recognition molecule Clec9A is expressed on the surface …
processes. The damaged cell-recognition molecule Clec9A is expressed on the surface …
[PDF][PDF] TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells
Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense
but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the …
but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the …