Internalization of exogenous macromolecules by live cells provides a powerful approach for
studying cellular functions. Understanding the mechanism of transfer from the extracellular …

The established view in cellular biology dictates that the cellular internalization of hydrophilic
macromolecules can only be achieved through the classical endocytosis pathway. However…

During the past fifteen years, a variety of peptides have been characterized for their ability to
translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes, …

The responses of vertebrate neurones to glutamate involve at least three receptor types 1 .
One of these, the NMDA receptor (so called because of its specific activation by N-methyl-D-…

The 60-amino acid long homeodomain of Antennapedia crosses biological membranes by
an energy-independent mechanism, a phenomenon abolished by directed mutagenesis …

We have recently reported that a 16-amino acid long polypeptide corresponding to the third
helix of the DNA binding domain (homeodomain) of Antennapedia, a Drosophila …

We synthesized the 60-amino acid polypeptide corresponding to the sequence of the Drosophila
antennapedia gene homeobox. This peptide (pAntp) recognized the consensus motif …

Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic
connections within visual cortex determine the timing of the critical period for rewiring ocular …

The amyloid precursor protein (APP) is a type I transmembrane protein of unknown physiological
function. Its soluble secreted form (sAPP) shows similarities with growth factors and …

Specific transfer of (orthodenticle homeobox 2) Otx2 homeoprotein into GABAergic interneurons
expressing parvalbumin (PV) is necessary and sufficient to open, then close, a critical …