Ablation of the cellular prion protein PrP C leads to a chronic demyelinating polyneuropathy
affecting Schwann cells. Neuron-restricted expression of PrP C prevents the disease 1 , …

Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous
system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons …

The myelin sheath surrounding axons ensures that nerve impulses travel quickly and efficiently,
allowing for the proper function of the vertebrate nervous system. We previously showed …

The G protein-coupled receptor (GPCR) superfamily represents the largest class of functionally
selective drug targets for disease modulation and therapy. GPCRs have been studied in …

Adhesion G protein-coupled receptors (aGPCRs) comprise the second largest yet least studied
class of the GPCR superfamily. aGPCRs are involved in many developmental processes …

During progression of melanoma, malignant melanocytes can be reprogrammed into
mesenchymal-like cells through a process similar to epithelial-mesenchymal transition (EMT), …

Despite their abundance and multiple functions in a variety of organ systems, the function
and signaling mechanisms of adhesion G protein-coupled receptors (GPCRs) are poorly …

Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a
human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Magnetic …

Schwann cells (SCs) are essential for proper peripheral nerve development and repair,
although the mechanisms regulating these processes are incompletely understood. We …

Aberrant expression of the presynaptic serotonin 1A receptor (5-HT 1A-R) because of a
polymorphism in the 5-HT 1A-R gene is associated with severe depression in human, whereas …