Radiosynthesis and Evaluation of [18F]Selectfluor bis(triflate)

H Teare, EG Robins, A Kirjavainen… - Angewandte Chemie …, 2010 - Wiley Online Library
Positron (β+) emission tomography (PET) is a noninvasive molecular imaging technique that
allows for the invivo investigation of physiological processes.[1] As a radioisotope, fluorine-…

Catalytic decarboxylative fluorination for the synthesis of tri-and difluoromethyl arenes

…, M O'Duill, J Wolstenhulme, AK Kirjavainen… - Organic …, 2013 - ACS Publications
Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under
Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave …

Hyperthyroidism increases brown fat metabolism in humans

…, T Noponen, A Kirjavainen… - The Journal of …, 2014 - academic.oup.com
Context: Thyroid hormones are important regulators of brown adipose tissue (BAT)
development and function. In rodents, BAT metabolism is up-regulated by thyroid hormones. …

[18 F] Fluorination of an arylboronic ester using [18 F] selectfluor bis (triflate): application to 6-[18 F] fluoro-l-DOPA

ISR Stenhagen, AK Kirjavainen, SJ Forsback… - Chemical …, 2013 - pubs.rsc.org
The Ag-mediated electrophilic [18F]fluorination of an arylboronic ester is reported. This new
radiochemical transformation uses [18F]selectfluor bis(triflate) in acetone. The process gave …

Secretin activates brown fat and induces satiation

…, T Välikangas, LL Elo, O Eskola, AK Kirjavainen… - Nature …, 2021 - nature.com
Brown adipose tissue (BAT) thermogenesis is activated by feeding. Recently, we revealed a
secretin-mediated gut–BAT–brain axis, which stimulates satiation in mice, but the purpose …

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease

…, K Varnäs, P Johnström, N Amini, A Kirjavainen… - Brain, 2015 - academic.oup.com
Impaired mitochondrial function, oxidative stress and formation of excessive levels of
reactive oxygen species play a key role in neurodegeneration in Parkinson’s disease. …

The SGLT2 inhibitor dapagliflozin reduces liver fat but does not affect tissue insulin sensitivity: a randomized, double-blind, placebo-controlled study with 8-week …

…, T Lehtimäki, J Saltevo, AK Kirjavainen… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE The aim of this study was to investigate tissue-specific effects of dapagliflozin
on insulin sensitivity and liver and body fat in patients with type 2 diabetes. RESEARCH …

Organomediated Enantioselective 18F Fluorination for PET Applications

F Buckingham, AK Kirjavainen, S Forsback… - Angewandte …, 2015 - Wiley Online Library
The first organomediated asymmetric 18 F fluorination has been accomplished using a chiral
imidazolidinone and [ 18 F]N‐fluorobenzenesulfonimide. The method provides access to …

[HTML][HTML] Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors

H Laine, M Sulg, A Kirjavainen, U Pirvola - Developmental biology, 2010 - Elsevier
Sensory hair cells and supporting cells of the mammalian cochlea and vestibular (balance)
organs exit the cell cycle during embryogenesis and do not proliferate thereafter. Here, we …

[HTML][HTML] Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB1 receptor availability

…, K Laitinen, N Houttu, AK Kirjavainen… - International Journal of …, 2022 - nature.com
Background Obesity is a pressing public health concern worldwide. Novel pharmacological
means are urgently needed to combat the increase of obesity and accompanying type 2 …