User profiles for A. M. Lauer
Amanda M. LauerJohns Hopkins University School of Medicine Verified email at jhmi.edu Cited by 1563 |
Efferent inhibition of the cochlea
PA Fuchs, AM Lauer - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Cholinergic efferent neurons originating in the brainstem innervate the acoustico-lateralis
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit hair …
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit hair …
Olivocochlear efferent effects on perception and behavior
The role of the mammalian auditory olivocochlear efferent system in hearing has long been
the subject of debate. Its ability to protect against damaging noise exposure is clear, but …
the subject of debate. Its ability to protect against damaging noise exposure is clear, but …
Sex-based differences in hearing loss: perspectives from non-clinical research to clinical outcomess
DF Villavisanis, ER Berson, AM Lauer… - Otology & …, 2020 - journals.lww.com
Objective: This article reviews the literature on recent non-clinical and clinical research
concerning sex-based differences in hearing loss primarily since 1993, and discusses …
concerning sex-based differences in hearing loss primarily since 1993, and discusses …
Cu (I)-catalyzed, α-selective, allylic alkylation reactions between phosphorothioate esters and organomagnesium reagents
AM Lauer, F Mahmud, J Wu - Journal of the American Chemical …, 2011 - ACS Publications
Regiocontrol of allylic alkylation reactions involving hard nucleophiles remains a significant
challenge and continues to be an active area of research. The lack of general methods in …
challenge and continues to be an active area of research. The lack of general methods in …
Palladium-catalyzed allylic fluorination of cinnamyl phosphorothioate esters
AM Lauer, J Wu - Organic letters, 2012 - ACS Publications
A highly regioselective, Pd-catalyzed allylic fluorination of phosphorothioate esters is reported.
This chemistry addresses several limitations of previously reported methods in which …
This chemistry addresses several limitations of previously reported methods in which …
Efferent synapses return to inner hair cells in the aging cochlea
Efferent innervation of the cochlea undergoes extensive modification early in development,
but it is unclear if efferent synapses are modified by age, hearing loss, or both. Structural …
but it is unclear if efferent synapses are modified by age, hearing loss, or both. Structural …
Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers
JS Wu, E Yi, M Manca, H Javaid, AM Lauer… - Elife, 2020 - elifesciences.org
… All of the mice were exposed five consecutive nights (approximately 9 PM – 9 AM),
except for one that was exposed for three consecutive nights, though the whole dataset was …
except for one that was exposed for three consecutive nights, though the whole dataset was …
Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related …
Age-related hearing loss is a very common sensory disability, affecting one in three older
adults. Establishing a link between anatomical, physiological, and behavioral markers of …
adults. Establishing a link between anatomical, physiological, and behavioral markers of …
[HTML][HTML] Mice lacking the alpha9 subunit of the nicotinic acetylcholine receptor exhibit deficits in frequency difference limens and sound localization
Sound processing in the cochlea is modulated by cholinergic efferent axons arising from
medial olivocochlear neurons in the brainstem. These axons contact outer hair cells in the …
medial olivocochlear neurons in the brainstem. These axons contact outer hair cells in the …
Acoustic startle modification as a tool for evaluating auditory function of the mouse: progress, pitfalls, and potential
AM Lauer, D Behrens, G Klump - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Acoustic startle response (ASR) modification procedures, especially prepulse inhibition (PPI),
are increasingly used as behavioral measures of auditory processing and sensorimotor …
are increasingly used as behavioral measures of auditory processing and sensorimotor …