User profiles for A. M. Lauer

Amanda M. Lauer

Johns Hopkins University School of Medicine
Verified email at jhmi.edu
Cited by 1563

Efferent inhibition of the cochlea

PA Fuchs, AM Lauer - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Cholinergic efferent neurons originating in the brainstem innervate the acoustico-lateralis
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit hair …

Olivocochlear efferent effects on perception and behavior

AM Lauer, SV Jimenez, PH Delano - Hearing research, 2022 - Elsevier
The role of the mammalian auditory olivocochlear efferent system in hearing has long been
the subject of debate. Its ability to protect against damaging noise exposure is clear, but …

Sex-based differences in hearing loss: perspectives from non-clinical research to clinical outcomess

DF Villavisanis, ER Berson, AM Lauer… - Otology & …, 2020 - journals.lww.com
Objective: This article reviews the literature on recent non-clinical and clinical research
concerning sex-based differences in hearing loss primarily since 1993, and discusses …

Cu (I)-catalyzed, α-selective, allylic alkylation reactions between phosphorothioate esters and organomagnesium reagents

AM Lauer, F Mahmud, J Wu - Journal of the American Chemical …, 2011 - ACS Publications
Regiocontrol of allylic alkylation reactions involving hard nucleophiles remains a significant
challenge and continues to be an active area of research. The lack of general methods in …

Palladium-catalyzed allylic fluorination of cinnamyl phosphorothioate esters

AM Lauer, J Wu - Organic letters, 2012 - ACS Publications
A highly regioselective, Pd-catalyzed allylic fluorination of phosphorothioate esters is reported.
This chemistry addresses several limitations of previously reported methods in which …

Efferent synapses return to inner hair cells in the aging cochlea

AM Lauer, PA Fuchs, DK Ryugo, HW Francis - Neurobiology of aging, 2012 - Elsevier
Efferent innervation of the cochlea undergoes extensive modification early in development,
but it is unclear if efferent synapses are modified by age, hearing loss, or both. Structural …

Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

JS Wu, E Yi, M Manca, H Javaid, AM Lauer… - Elife, 2020 - elifesciences.org
… All of the mice were exposed five consecutive nights (approximately 9 PM – 9 AM),
except for one that was exposed for three consecutive nights, though the whole dataset was …

Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related …

…, R Board, DF Villavisanis, ML Dent, AM Lauer - Neurobiology of …, 2020 - Elsevier
Age-related hearing loss is a very common sensory disability, affecting one in three older
adults. Establishing a link between anatomical, physiological, and behavioral markers of …

[HTML][HTML] Mice lacking the alpha9 subunit of the nicotinic acetylcholine receptor exhibit deficits in frequency difference limens and sound localization

A Clause, AM Lauer, K Kandler - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Sound processing in the cochlea is modulated by cholinergic efferent axons arising from
medial olivocochlear neurons in the brainstem. These axons contact outer hair cells in the …

Acoustic startle modification as a tool for evaluating auditory function of the mouse: progress, pitfalls, and potential

AM Lauer, D Behrens, G Klump - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Acoustic startle response (ASR) modification procedures, especially prepulse inhibition (PPI),
are increasingly used as behavioral measures of auditory processing and sensorimotor …