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Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.
Li YC, Panikker P, Xing B, Yang SS, Alexandropoulos C, McEachern EP, Akumuo R, Zhao E, Gulchina Y, Pletnikov MV, Urs NM, Caron MG, Elefant F, Gao WJ. Li YC, et al. Among authors: gulchina y. Biol Psychiatry. 2020 Apr 15;87(8):745-755. doi: 10.1016/j.biopsych.2019.10.025. Epub 2019 Nov 6. Biol Psychiatry. 2020. PMID: 31892408 Free PMC article.
Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia.
Li ML, Gulchina Y, Monaco SA, Xing B, Ferguson BR, Li YC, Li F, Hu XQ, Gao WJ. Li ML, et al. Among authors: gulchina y. Neurobiol Learn Mem. 2017 Apr;140:52-61. doi: 10.1016/j.nlm.2017.02.004. Epub 2017 Feb 16. Neurobiol Learn Mem. 2017. PMID: 28213064 Free PMC article.
LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.
Li ML, Yang SS, Xing B, Ferguson BR, Gulchina Y, Li YC, Li F, Hu XQ, Gao WJ. Li ML, et al. Among authors: gulchina y. Exp Neurol. 2015 Nov;273:190-201. doi: 10.1016/j.expneurol.2015.08.019. Epub 2015 Sep 1. Exp Neurol. 2015. PMID: 26341392 Free PMC article.