Abstract
Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Animals, Genetically Modified
-
Conditioning, Classical
-
Cyclic AMP Response Element-Binding Protein / genetics*
-
Cyclic AMP Response Element-Binding Protein / physiology
-
Drosophila / genetics*
-
Drosophila / physiology
-
Gene Expression*
-
Genes, Dominant / physiology
-
Genes, Insect / physiology*
-
Hot Temperature
-
Memory / physiology*
-
Molecular Sequence Data
-
RNA, Messenger / biosynthesis
Substances
-
Cyclic AMP Response Element-Binding Protein
-
RNA, Messenger