GAPs for rho-related GTPases

N Lamarche; A Hall

doi:10.1016/0168-9525(94)90114-7

GAPs for rho-related GTPases

Trends Genet. 1994 Dec;10(12):436-40. doi: 10.1016/0168-9525(94)90114-7.

Authors

N Lamarche¹, A Hall

Affiliation

¹ MRC Laboratory for Molecular Cell Biology, University College London, UK.

PMID: 7871593
DOI: 10.1016/0168-9525(94)90114-7

Abstract

Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified. Here, we discuss the nature of such GTPase-activating proteins (GAPs) and their potential importance for cell signalling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Caenorhabditis elegans / metabolism
Drosophila / metabolism
GTP Phosphohydrolases / metabolism*
GTP-Binding Proteins / metabolism*
GTPase-Activating Proteins*
Humans
Mammals
Saccharomyces cerevisiae / metabolism

Substances

GTPase-Activating Proteins
rho GTPase-activating protein
GTP Phosphohydrolases
GTP-Binding Proteins