A Brief History of Long-Term Potentiation

Neuron. 2017 Jan 18;93(2):281-290. doi: 10.1016/j.neuron.2016.12.015.

Abstract

Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been published on this intriguing phenomenon, which provides a compelling cellular model for learning and memory. Although LTP has suffered considerable growing pains over the years, LTP has finally come of age. Here the rich history of LTP is reviewed. These are exciting times and the pace of discovery is remarkable.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • CA1 Region, Hippocampal / physiology
  • CA3 Region, Hippocampal / physiology
  • Hippocampus / physiology*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Long-Term Potentiation / physiology*
  • Memory / physiology*
  • Mossy Fibers, Hippocampal / physiology*
  • Neurosciences / history
  • Pyramidal Cells / physiology*
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Synapses / physiology*

Substances

  • Receptors, N-Methyl-D-Aspartate