Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis

Jan A Gorter; Erwin A van Vliet; Eleonora Aronica

doi:10.1016/j.yebeh.2015.04.047

Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis

Epilepsy Behav. 2015 Aug:49:13-6. doi: 10.1016/j.yebeh.2015.04.047. Epub 2015 May 6.

Authors

Jan A Gorter¹, Erwin A van Vliet², Eleonora Aronica³

Affiliations

¹ Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: j.a.gorter@uva.nl.
² Academic Medical Center, Department of (Neuro)Pathology, University of Amsterdam, Amsterdam, The Netherlands.
³ Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; Academic Medical Center, Department of (Neuro)Pathology, University of Amsterdam, Amsterdam, The Netherlands; SEIN - Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands.

PMID: 25958228
DOI: 10.1016/j.yebeh.2015.04.047

Abstract

Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. This article is part of a Special Issue entitled "Status Epilepticus".

Keywords: Angiogenesis; Blood–brain barrier; Epilepsy; Immune response; Inflammation; Leakage; Status epilepticus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Blood-Brain Barrier / physiopathology*
Humans
Inflammation / physiopathology*
Rats
Rats, Sprague-Dawley
Status Epilepticus / physiopathology*