Abstract
Neurons in different locations across the cortex are connected through polysynaptic networks involving both excitation and inhibition. To probe the functional effect of such networks, we used optogenetic stimulation to trigger antidromic spikes in a local region of primary visual cortex (V1). This local activity had two effects at distal V1 locations: summation and division. The balance between the two depended on visual contrast, and a normalization model precisely captured these effects.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
-
Action Potentials / drug effects
-
Action Potentials / physiology*
-
Animals
-
Channelrhodopsins
-
Electric Stimulation
-
Electroporation
-
Excitatory Amino Acid Antagonists / pharmacology
-
Female
-
In Vitro Techniques
-
Luminescent Proteins / genetics
-
Male
-
Mice
-
Mice, Inbred C57BL
-
Mice, Transgenic
-
Models, Neurological
-
Nerve Net / physiology*
-
Neurons / physiology*
-
Optogenetics
-
Photic Stimulation
-
Pregnancy
-
Red Fluorescent Protein
-
Statistics, Nonparametric
-
Valine / analogs & derivatives
-
Valine / pharmacology
-
Visual Cortex / cytology*
-
Visual Pathways / drug effects
-
Visual Pathways / physiology*
-
Visual Perception / physiology*
-
Visual Perception / radiation effects
Substances
-
Channelrhodopsins
-
Excitatory Amino Acid Antagonists
-
Luminescent Proteins
-
6-Cyano-7-nitroquinoxaline-2,3-dione
-
2-amino-5-phosphopentanoic acid
-
Valine