Generation of transplantable striatal projection neurons from human ESCs

Malin Parmar; Anders Björklund

doi:10.1016/j.stem.2012.03.004

Generation of transplantable striatal projection neurons from human ESCs

Cell Stem Cell. 2012 Apr 6;10(4):349-50. doi: 10.1016/j.stem.2012.03.004.

Authors

Malin Parmar¹, Anders Björklund

Affiliation

¹ Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden.

PMID: 22482498
DOI: 10.1016/j.stem.2012.03.004

Abstract

In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.

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