Status epilepticus: a review, with emphasis on refractory cases

Can J Neurol Sci. 2012 Mar;39(2):157-69. doi: 10.1017/s0317167100013160.

Abstract

Status epilepticus is among the most dramatic of clinical presentations encountered by emergency room physicians, neurologists, neurosurgeons and intensivists. While progress in its management has been aided significantly with an increasing number of effective treatment options, improved diagnostic methods and more effective monitoring, poor outcomes and diagnostic failures are still frequently encountered. Refractory cases still carry significant morbidity and mortality rates, including poor cognitive outcomes. This review discusses basic pathophysiology and management of status epilepticus, neuroimaging findings, the role of continuous electroencephalogram monitoring and nonconvulsive status epilepticusas well as recent developments in treatment options for refractory cases.

Publication types

  • Review

MeSH terms

  • Brain / physiopathology*
  • Electroencephalography
  • Humans
  • Neuroimaging
  • Status Epilepticus / diagnosis*
  • Status Epilepticus / physiopathology
  • Status Epilepticus / therapy*