Abstract
We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / physiology
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Afferent Pathways / physiology
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Animals
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Channelrhodopsins
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Cortical Synchronization / physiology*
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Denervation
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Electric Stimulation / methods
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Fourier Analysis
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Mice
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Mice, Transgenic
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Neurons / physiology
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Somatosensory Cortex / cytology
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Somatosensory Cortex / physiology*
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Thalamus / cytology
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Thalamus / physiology*
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Vibrissae / innervation
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Wakefulness