Abstract
Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Disease Models, Animal
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Electroencephalography / methods
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Enzyme Inhibitors / adverse effects
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Epilepsy / chemically induced
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Epilepsy / drug therapy
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Epilepsy / metabolism*
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Epilepsy / physiopathology
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Female
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Finasteride / adverse effects
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Gonadotropins / therapeutic use
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Lithium
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Neurotransmitter Agents / antagonists & inhibitors
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Neurotransmitter Agents / metabolism*
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Pilocarpus
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Pregnanolone / therapeutic use
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Rats
Substances
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Enzyme Inhibitors
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Gonadotropins
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Neurotransmitter Agents
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Finasteride
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Lithium
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Pregnanolone