Abstract
In this issue of Neuron, Richardson-Jones et al. report on a novel genetic approach to conditionally and specifically dampen the function of the 5-HT(1A) autoreceptor in mice to study its role on the 5-HT system and on the antidepressant-like effect of the selective serotonin reuptake inhibitor (SSRI) fluoxetine.
MeSH terms
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Animals
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Antidepressive Agents, Second-Generation / metabolism*
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Antidepressive Agents, Second-Generation / therapeutic use
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Depressive Disorder, Major / drug therapy
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Fluoxetine / metabolism*
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Fluoxetine / therapeutic use
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Humans
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Mice
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Neurons / cytology
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Neurons / metabolism
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Receptor, Serotonin, 5-HT1A / genetics
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Receptor, Serotonin, 5-HT1A / metabolism*
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Serotonin / metabolism*
Substances
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Antidepressive Agents, Second-Generation
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Fluoxetine
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Receptor, Serotonin, 5-HT1A
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Serotonin