Altered function of the serotonin 1A autoreceptor and the antidepressant response

Neuron. 2010 Jan 14;65(1):1-2. doi: 10.1016/j.neuron.2009.12.028.

Abstract

In this issue of Neuron, Richardson-Jones et al. report on a novel genetic approach to conditionally and specifically dampen the function of the 5-HT(1A) autoreceptor in mice to study its role on the 5-HT system and on the antidepressant-like effect of the selective serotonin reuptake inhibitor (SSRI) fluoxetine.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antidepressive Agents, Second-Generation / metabolism*
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Depressive Disorder, Major / drug therapy
  • Fluoxetine / metabolism*
  • Fluoxetine / therapeutic use
  • Humans
  • Mice
  • Neurons / cytology
  • Neurons / metabolism
  • Receptor, Serotonin, 5-HT1A / genetics
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Serotonin / metabolism*

Substances

  • Antidepressive Agents, Second-Generation
  • Fluoxetine
  • Receptor, Serotonin, 5-HT1A
  • Serotonin