Abstract
Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 microg/0.5 microl), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Appetite / drug effects
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Dietary Fats
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Drinking Behavior / drug effects
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Eating / drug effects
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology
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Feeding Behavior / drug effects*
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Food Deprivation
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Male
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Microinjections
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Muscarinic Antagonists / pharmacology*
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Neurotransmitter Agents / pharmacology
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Nucleus Accumbens / drug effects*
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Nucleus Accumbens / physiology
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Rats
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Rats, Sprague-Dawley
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Receptors, Opioid, mu / drug effects
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Receptors, Opioid, mu / physiology*
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Scopolamine / pharmacology*
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Time Factors
Substances
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Dietary Fats
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Muscarinic Antagonists
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Neurotransmitter Agents
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Receptors, Opioid, mu
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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Scopolamine